MAP1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032355Biological processresponse to estradiol
GO_0045773Biological processpositive regulation of axon extension
GO_0031175Biological processneuron projection development
GO_0047497Biological processmitochondrion transport along microtubule
GO_0001764Biological processneuron migration
GO_0033189Biological processresponse to vitamin A
GO_0014012Biological processperipheral nervous system axon regeneration
GO_0071363Biological processcellular response to growth factor stimulus
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0031114Biological processregulation of microtubule depolymerization
GO_0007409Biological processaxonogenesis
GO_0032387Biological processnegative regulation of intracellular transport
GO_0051915Biological processinduction of synaptic plasticity by chemical substance
GO_0071895Biological processodontoblast differentiation
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0009743Biological processresponse to carbohydrate
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0048675Biological processaxon extension
GO_0009612Biological processresponse to mechanical stimulus
GO_0007416Biological processsynapse assembly
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0016358Biological processdendrite development
GO_0001578Biological processmicrotubule bundle formation
GO_0017085Biological processresponse to insecticide
GO_0061162Biological processestablishment of monopolar cell polarity
GO_0021700Biological processdevelopmental maturation
GO_0097441Cellular componentbasal dendrite
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0043197Cellular componentdendritic spine
GO_0001750Cellular componentphotoreceptor outer segment
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0036477Cellular componentsomatodendritic compartment
GO_0043204Cellular componentperikaryon
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0043196Cellular componentvaricosity
GO_0097457Cellular componenthippocampal mossy fiber
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0097440Cellular componentapical dendrite
GO_0030424Cellular componentaxon
GO_0005875Cellular componentmicrotubule associated complex
GO_0005543Molecular functionphospholipid binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0003779Molecular functionactin binding
GO_0005198Molecular functionstructural molecule activity
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP1B
Protein nameMicrotubule-associated protein 1B
MAP1B protein
Microtubule associated protein 1B
Microtubule-associated protein 1B (MAP-1B) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1]
SynonymshCG_37848
DescriptionFUNCTION: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension . Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. .

AccessionsENST00000512974.5
Q05BW8
A5D6X1
A5D8X6
Q32NB7
Q6PJD3
ENST00000511641.2
Q86X89
ENST00000504492.1
Q4VBY4
D6RA32
A2BDK6
P46821
D6RCL2
D6RA40
D6RGJ3
ENST00000513526.6
ENST00000296755.12