SLC9A5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC9A5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC9A5 at tissue level.

III. Associated gene sets

GO_0098719Biological processsodium ion import across plasma membrane
GO_0006811Biological processmonoatomic ion transport
GO_0051453Biological processregulation of intracellular pH
GO_0035725Biological processsodium ion transmembrane transport
GO_0071805Biological processpotassium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0044309Cellular componentneuron spine
GO_0032591Cellular componentdendritic spine membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0005925Cellular componentfocal adhesion
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_1990763Molecular functionarrestin family protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC9A5
Protein nameSodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5)
Solute carrier family 9 member A5
SynonymsNHE5
DescriptionFUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues . Acts as a negative regulator of dendritic spine growth . Plays a role in postsynaptic remodeling and signaling . Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking . .

AccessionsJ3KSE2
Q14940
J3QRV1
J3KSB3
H3BNY2
ENST00000566345.6
ENST00000566626.1
ENST00000299798.16
ENST00000567247.6
ENST00000564812.5