SLC4A10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	74% ± 22%	Explore
oligodendrocyte precursor cell	12 studies	32% ± 12%	Explore
mucosal invariant T cell	11 studies	32% ± 11%	Explore
GABAergic neuron	10 studies	61% ± 27%	Explore
interneuron	6 studies	70% ± 24%	Explore
neuron	5 studies	37% ± 16%	Explore
retinal bipolar neuron	5 studies	58% ± 23%	Explore
amacrine cell	5 studies	46% ± 25%	Explore
granule cell	4 studies	48% ± 20%	Explore
endothelial cell	3 studies	52% ± 19%	Explore
GABAergic interneuron	3 studies	72% ± 12%	Explore
microglial cell	3 studies	40% ± 17%	Explore
GABAergic amacrine cell	3 studies	51% ± 21%	Explore
OFF-bipolar cell	3 studies	51% ± 23%	Explore
ON-bipolar cell	3 studies	72% ± 20%	Explore
glycinergic amacrine cell	3 studies	43% ± 16%	Explore
rod bipolar cell	3 studies	78% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	49% ± 24%	Explore
eye	4 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	91%	2940.17	2398 / 2642	88%	10.79	623 / 705
adrenal gland	5%	15.75	13 / 258	36%	3.69	82 / 230
pancreas	3%	9.18	11 / 328	30%	1.19	53 / 178
spleen	32%	88.96	78 / 241	0%	0	0 / 0
intestine	17%	83.85	163 / 966	4%	0.19	22 / 527
breast	0%	0	0 / 459	10%	1.08	107 / 1118
prostate	0%	0	0 / 245	8%	0.20	38 / 502
peripheral blood	5%	18.36	46 / 929	0%	0	0 / 0
stomach	0%	0	0 / 359	4%	0.25	11 / 286
lymph node	0%	0	0 / 0	3%	0.23	1 / 29
eye	0%	0	0 / 0	3%	0.18	2 / 80
lung	1%	1.91	4 / 578	2%	0.04	19 / 1155
esophagus	0%	0	0 / 1445	2%	0.06	4 / 183
bladder	0%	0	0 / 21	1%	0.02	7 / 504
kidney	0%	0	0 / 89	1%	0.06	12 / 901
uterus	0%	0	0 / 170	1%	0.04	6 / 459
thymus	0%	0	0 / 653	1%	0.01	4 / 605
skin	0%	0.44	3 / 1809	0%	0.00	1 / 472
liver	0%	0	0 / 226	0%	0.01	1 / 406
ovary	0%	0	0 / 180	0%	0.01	1 / 430
adipose	0%	0.33	2 / 1204	0%	0	0 / 0
blood vessel	0%	0.19	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007601	Biological process	visual perception
GO_0009791	Biological process	post-embryonic development
GO_0006821	Biological process	chloride transport
GO_0098656	Biological process	monoatomic anion transmembrane transport
GO_0021860	Biological process	pyramidal neuron development
GO_0055085	Biological process	transmembrane transport
GO_0035264	Biological process	multicellular organism growth
GO_0009416	Biological process	response to light stimulus
GO_0048854	Biological process	brain morphogenesis
GO_0051453	Biological process	regulation of intracellular pH
GO_0015701	Biological process	bicarbonate transport
GO_0035641	Biological process	locomotory exploration behavior
GO_0048172	Biological process	regulation of short-term neuronal synaptic plasticity
GO_0035725	Biological process	sodium ion transmembrane transport
GO_1902600	Biological process	proton transmembrane transport
GO_0097441	Cellular component	basal dendrite
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0036477	Cellular component	somatodendritic compartment
GO_0043204	Cellular component	perikaryon
GO_0043679	Cellular component	axon terminus
GO_0098794	Cellular component	postsynapse
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0045202	Cellular component	synapse
GO_0097440	Cellular component	apical dendrite
GO_0097442	Cellular component	CA3 pyramidal cell dendrite
GO_0016323	Cellular component	basolateral plasma membrane
GO_0140892	Molecular function	sodium,bicarbonate:chloride antiporter activity
GO_0005452	Molecular function	solute:inorganic anion antiporter activity
GO_0008510	Molecular function	sodium:bicarbonate symporter activity

IV. Literature review

[source]

Gene name	SLC4A10
Protein name	Solute carrier family 4 member 10 Anion exchange protein Uncharacterized protein SLC4A10 Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)
Synonyms	NCBE NBCN2
Description	FUNCTION: Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH . Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange . Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). .
Accessions	ENST00000446228.5 ENST00000421911.1 ENST00000375514.9 [Q6U841-3] Q53SB3 F8WDX9 ENST00000415876.6 [Q6U841-2] ENST00000446997.6 [Q6U841-1] C9J240 ENST00000272716.9 E7EW28 Q6U841

SLC4A10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review