AKR1A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044597Biological processdaunorubicin metabolic process
GO_0044598Biological processdoxorubicin metabolic process
GO_0019853Biological processL-ascorbic acid biosynthetic process
GO_0019640Biological processglucuronate catabolic process to xylulose 5-phosphate
GO_0043066Biological processnegative regulation of apoptotic process
GO_0046185Biological processaldehyde catabolic process
GO_0110095Biological processcellular detoxification of aldehyde
GO_1901687Biological processglutathione derivative biosynthetic process
GO_0006629Biological processlipid metabolic process
GO_0042840Biological processD-glucuronate catabolic process
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0047655Molecular functionallyl-alcohol dehydrogenase activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0160163Molecular functionS-nitrosoglutathione reductase (NADPH) activity
GO_1990002Molecular functionmethylglyoxal reductase (NADPH) (acetol producing) activity
GO_0004033Molecular functionaldo-keto reductase (NADPH) activity
GO_0080007Molecular functionS-nitrosoglutathione reductase (NADH) activity
GO_0047941Molecular functionglucuronolactone reductase activity
GO_0047939Molecular functionL-glucuronate reductase activity
GO_0047956Molecular functionglycerol dehydrogenase (NADP+) activity
GO_0004745Molecular functionall-trans-retinol dehydrogenase (NAD+) activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKR1A1
Protein nameAldo-keto reductase family 1 member A1 (EC 1.1.1.2) (EC 1.1.1.372) (EC 1.1.1.54) (Alcohol dehydrogenase [NADP(+)]) (Aldehyde reductase) (Glucuronate reductase) (EC 1.1.1.19) (Glucuronolactone reductase) (EC 1.1.1.20)
Aldo-keto reductase family 1 member A1
SynonymsALR
ALDR1
DescriptionFUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde . Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) . Displays no reductase activity towards retinoids (By similarity). .

AccessionsENST00000351829.9
ENST00000471651.1
ENST00000372070.7
P14550
Q5T621
V9GYG2
ENST00000481885.5
ENST00000621846.4
V9GYP9
ENST00000434299.5