TENM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098942Biological processretrograde trans-synaptic signaling by trans-synaptic protein complex
GO_0007165Biological processsignal transduction
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0048666Biological processneuron development
GO_0098609Biological processcell-cell adhesion
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0030175Cellular componentfilopodium
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0030426Cellular componentgrowth cone
GO_0016605Cellular componentPML body
GO_0045211Cellular componentpostsynaptic membrane
GO_0030054Cellular componentcell junction
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0050839Molecular functioncell adhesion molecule binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameTENM2
Protein nameTeneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]
HCG38403, isoform CRA_b (Teneurin transmembrane protein 2)
Teneurin transmembrane protein 2
SynonymsTNM2
KIAA1127
ODZ2
hCG_38403
DescriptionFUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. .; FUNCTION: [Isoform 2]: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. .; FUNCTION: [Ten-2 intracellular domain]: Induces gene transcription inhibition. .

AccessionsA0A8Q3SIA3
ENST00000518659.6 [Q9NT68-1]
F8VNQ3
ENST00000695885.1
ENST00000695961.1
A0A8Q3SIB5
A0A8Q3SI53
A0A8Q3SI97
ENST00000695962.1
ENST00000520394.5
Q9NT68
ENST00000695886.1
G3V106
ENST00000519204.5