SLC1A3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	28 studies	40% ± 21%	Explore
astrocyte	23 studies	78% ± 16%	Explore
microglial cell	18 studies	75% ± 17%	Explore
oligodendrocyte	15 studies	41% ± 12%	Explore
oligodendrocyte precursor cell	15 studies	42% ± 15%	Explore
myeloid cell	10 studies	38% ± 19%	Explore
adipocyte	10 studies	58% ± 15%	Explore
endothelial cell	7 studies	41% ± 17%	Explore
Mueller cell	6 studies	82% ± 4%	Explore
cardiac muscle cell	5 studies	62% ± 17%	Explore
dendritic cell	5 studies	23% ± 6%	Explore
GABAergic neuron	4 studies	27% ± 9%	Explore
pericyte	4 studies	47% ± 18%	Explore
mononuclear phagocyte	3 studies	44% ± 18%	Explore
conventional dendritic cell	3 studies	25% ± 4%	Explore
smooth muscle cell	3 studies	61% ± 27%	Explore
ependymal cell	3 studies	74% ± 15%	Explore
alveolar macrophage	3 studies	40% ± 5%	Explore
monocyte	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	34% ± 16%	Explore
eye	4 studies	19% ± 2%	Explore
heart	4 studies	33% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	43720.68	2638 / 2642	100%	608.25	705 / 705
ovary	32%	1478.71	58 / 180	95%	24.03	410 / 430
breast	38%	2696.76	175 / 459	71%	9.34	799 / 1118
lung	28%	1126.37	163 / 578	69%	12.27	800 / 1155
lymph node	0%	0	0 / 0	83%	21.32	24 / 29
tonsil	0%	0	0 / 0	82%	16.56	37 / 45
uterus	0%	0	0 / 170	68%	17.31	310 / 459
esophagus	8%	265.11	113 / 1445	58%	8.11	107 / 183
pancreas	1%	20.65	2 / 328	64%	9.52	114 / 178
skin	5%	183.19	95 / 1809	59%	9.70	277 / 472
adipose	62%	4667.12	744 / 1204	0%	0	0 / 0
kidney	1%	53.66	1 / 89	60%	9.82	543 / 901
bladder	5%	175.52	1 / 21	51%	9.58	255 / 504
adrenal gland	20%	731.13	51 / 258	33%	10.89	77 / 230
heart	49%	3080.99	424 / 861	0%	0	0 / 0
prostate	1%	27.36	2 / 245	29%	2.16	146 / 502
stomach	1%	39.89	3 / 359	28%	3.22	81 / 286
thymus	3%	100.37	18 / 653	24%	2.40	147 / 605
spleen	22%	776.02	53 / 241	0%	0	0 / 0
liver	0%	0	0 / 226	20%	2.32	81 / 406
intestine	1%	59.50	11 / 966	18%	2.33	97 / 527
eye	0%	0	0 / 0	19%	6.97	15 / 80
muscle	12%	447.24	95 / 803	0%	0	0 / 0
blood vessel	8%	433.80	113 / 1335	0%	0	0 / 0
peripheral blood	1%	35.00	10 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0070779	Biological process	D-aspartate import across plasma membrane
GO_0007605	Biological process	sensory perception of sound
GO_0031223	Biological process	auditory behavior
GO_0070633	Biological process	transepithelial transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0015813	Biological process	L-glutamate transmembrane transport
GO_0006811	Biological process	monoatomic ion transport
GO_0098712	Biological process	L-glutamate import across plasma membrane
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0006883	Biological process	intracellular sodium ion homeostasis
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0048667	Biological process	cell morphogenesis involved in neuron differentiation
GO_0015804	Biological process	neutral amino acid transport
GO_0071314	Biological process	cellular response to cocaine
GO_0001504	Biological process	neurotransmitter uptake
GO_1902476	Biological process	chloride transmembrane transport
GO_0007268	Biological process	chemical synaptic transmission
GO_0046677	Biological process	response to antibiotic
GO_0051938	Biological process	L-glutamate import
GO_0006836	Biological process	neurotransmitter transport
GO_0009416	Biological process	response to light stimulus
GO_0050806	Biological process	positive regulation of synaptic transmission
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0140009	Biological process	L-aspartate import across plasma membrane
GO_0009611	Biological process	response to wounding
GO_0021545	Biological process	cranial nerve development
GO_0009449	Biological process	gamma-aminobutyric acid biosynthetic process
GO_0098796	Cellular component	membrane protein complex
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0043025	Cellular component	neuronal cell body
GO_0009925	Cellular component	basal plasma membrane
GO_0043005	Cellular component	neuron projection
GO_0009986	Cellular component	cell surface
GO_0045202	Cellular component	synapse
GO_0015501	Molecular function	glutamate:sodium symporter activity
GO_0016595	Molecular function	glutamate binding
GO_0015175	Molecular function	neutral L-amino acid transmembrane transporter activity
GO_0005313	Molecular function	L-glutamate transmembrane transporter activity
GO_0046872	Molecular function	metal ion binding
GO_0005314	Molecular function	high-affinity L-glutamate transmembrane transporter activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SLC1A3
Protein name	SLC1A3 protein (Solute carrier family 1 member 3) Amino acid transporter Excitatory amino acid transporter 1 (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) Solute carrier family 1 member 3
Synonyms	GLAST GLAST1 EAAT1
Description	FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate . Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion . Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport . Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). .
Accessions	ENST00000679852.1 ENST00000681480.1 ENST00000680232.1 ENST00000612708.5 ENST00000265113.9 [P43003-1] A0A7P0T8H5 ENST00000679423.1 A0A7P0Z4R4 ENST00000512374.1 A0A087WT87 ENST00000681926.1 [P43003-2] ENST00000681701.1 A0A7P0TAW2 ENST00000679992.1 [P43003-1] A0A7P0Z4F7 ENST00000680835.1 A0A7P0TA03 ENST00000680908.1 ENST00000680655.1 E7EUV6 ENST00000681440.1 ENST00000679784.1 ENST00000679487.1 ENST00000681795.1 A0A7P0T807 ENST00000680890.1 A0A7P0T800 A0A7P0T8R2 A0A7P0T9A4 ENST00000513646.1 ENST00000680125.1 [P43003-2] ENST00000679983.1 [P43003-1] ENST00000513903.5 ENST00000504121.5 ENST00000613445.5 A0A7P0TAG7 ENST00000679958.1 ENST00000681776.1 ENST00000680527.1 ENST00000681909.1 A0A087X0U3 E7EUS7 Q7Z5T0 P43003 ENST00000680048.1 A0A7P0T8Q1 A0A7P0TB50 A0A7P0T8T4 A0A7P0TAF5 A0A7P0T7Q9 ENST00000680369.1 ENST00000505202.5 A0A7P0T9Z4 ENST00000681726.1 A0A7P0T8P5 Q8N169 A0A7P0T9P1 A0A7P0T911 ENST00000681854.1 ENST00000680318.1 [P43003-1] ENST00000381918.4 [P43003-1]

SLC1A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review