SLC8A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0042552Biological processmyelination
GO_0007612Biological processlearning
GO_0007611Biological processlearning or memory
GO_0006811Biological processmonoatomic ion transport
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0060291Biological processlong-term synaptic potentiation
GO_0098815Biological processmodulation of excitatory postsynaptic potential
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_0048709Biological processoligodendrocyte differentiation
GO_0007154Biological processcell communication
GO_0007613Biological processmemory
GO_0014819Biological processregulation of skeletal muscle contraction
GO_1903779Biological processregulation of cardiac conduction
GO_0006851Biological processmitochondrial calcium ion transmembrane transport
GO_0050808Biological processsynapse organization
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0071456Biological processcellular response to hypoxia
GO_0016528Cellular componentsarcoplasm
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043204Cellular componentperikaryon
GO_0042383Cellular componentsarcolemma
GO_0043679Cellular componentaxon terminus
GO_0098794Cellular componentpostsynapse
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0070161Cellular componentanchoring junction
GO_0014069Cellular componentpostsynaptic density
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030424Cellular componentaxon
GO_0046872Molecular functionmetal ion binding
GO_0099580Molecular functionmonoatomic ion antiporter activity involved in regulation of postsynaptic membrane potential
GO_0005432Molecular functioncalcium:sodium antiporter activity
GO_0005516Molecular functioncalmodulin binding

IV. Literature review

[source]
Gene nameSLC8A3
Protein nameSolute carrier family 8 member A3
Alternative protein SLC8A3
Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3)
SLC8A3 protein
SynonymsNCX3
DescriptionFUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination . Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). .

AccessionsENST00000216568.11 [P57103-5]
A7E240
ENST00000533541.1
ENST00000494208.5 [P57103-3]
ENST00000394330.6 [P57103-4]
ENST00000528359.6 [P57103-7]
ENST00000705391.1 [P57103-2]
P57103
A7E249
ENST00000356921.7 [P57103-2]
F2Z391
L8E9C0
ENST00000381269.6 [P57103-1]
ENST00000534137.5 [P57103-6]