HAPLN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HAPLN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HAPLN4 at tissue level.

III. Associated gene sets

GO_0002052Biological processpositive regulation of neuroblast proliferation
GO_0001501Biological processskeletal system development
GO_0010001Biological processglial cell differentiation
GO_0051932Biological processsynaptic transmission, GABAergic
GO_1904862Biological processinhibitory synapse assembly
GO_0007155Biological processcell adhesion
GO_0007417Biological processcentral nervous system development
GO_0005615Cellular componentextracellular space
GO_0045202Cellular componentsynapse
GO_0072534Cellular componentperineuronal net
GO_0150043Molecular functionstructural constituent of synapse-associated extracellular matrix
GO_0005540Molecular functionhyaluronic acid binding

IV. Literature review

[source]
Gene nameHAPLN4
Protein nameHyaluronan and proteoglycan link protein 4 (Brain link protein 2)
SynonymsBRAL2
KIAA1926
DescriptionFUNCTION: Essential for the proper localization of brevican (BCAN), mainly as a perineuronal nets (PNNs)-type deposition in the brainstem and cerebellum thereby playing a key role in the formation and structural organization of PNNs (By similarity). Contributes to the formation and transmission of inhibitory GABAergic synapses between Purkinje cells and deep cerebellar nuclei neurons (By similarity). .

AccessionsQ86UW8
ENST00000291481.8