ADARB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006382Biological processadenosine to inosine editing
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0021965Biological processspinal cord ventral commissure morphogenesis
GO_0006397Biological processmRNA processing
GO_0016553Biological processbase conversion or substitution editing
GO_0060415Biological processmuscle tissue morphogenesis
GO_0044387Biological processnegative regulation of protein kinase activity by regulation of protein phosphorylation
GO_0061744Biological processmotor behavior
GO_0045087Biological processinnate immune response
GO_0006396Biological processRNA processing
GO_0051607Biological processdefense response to virus
GO_0035264Biological processmulticellular organism growth
GO_0007274Biological processneuromuscular synaptic transmission
GO_0050884Biological processneuromuscular process controlling posture
GO_0045070Biological processpositive regulation of viral genome replication
GO_0021618Biological processhypoglossal nerve morphogenesis
GO_0097049Biological processmotor neuron apoptotic process
GO_0030336Biological processnegative regulation of cell migration
GO_0060384Biological processinnervation
GO_0021610Biological processfacial nerve morphogenesis
GO_0051726Biological processregulation of cell cycle
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0003726Molecular functiondouble-stranded RNA adenosine deaminase activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0008251Molecular functiontRNA-specific adenosine deaminase activity
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameADARB1
Protein nameDouble-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase)
Adenosine deaminase RNA specific B1
SynonymsDRADA2
ADAR2
RED1
DescriptionFUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. .; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. .; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. .

AccessionsENST00000389861.7 [P78563-2]
ENST00000705392.1
A0A994J7T5
ENST00000705393.1
ENST00000389863.8 [P78563-3]
ENST00000360697.4 [P78563-1]
ENST00000496664.5 [P78563-1]
ENST00000437626.5 [P78563-1]
ENST00000492414.5 [P78563-2]
ENST00000449478.2
ENST00000348831.9 [P78563-2]
P78563
ENST00000449478.2 [P78563-1]
A0A0A0MSG8
A0A994J4V7