WASF2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	42% ± 15%	Explore
fibroblast	42 studies	34% ± 9%	Explore
B cell	41 studies	33% ± 12%	Explore
macrophage	41 studies	37% ± 14%	Explore
pericyte	36 studies	37% ± 13%	Explore
natural killer cell	33 studies	31% ± 9%	Explore
smooth muscle cell	30 studies	34% ± 11%	Explore
CD4-positive, alpha-beta T cell	30 studies	26% ± 9%	Explore
conventional dendritic cell	28 studies	34% ± 15%	Explore
CD8-positive, alpha-beta T cell	27 studies	26% ± 9%	Explore
regulatory T cell	25 studies	30% ± 8%	Explore
non-classical monocyte	24 studies	56% ± 19%	Explore
T cell	23 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	23 studies	43% ± 12%	Explore
monocyte	22 studies	38% ± 11%	Explore
classical monocyte	22 studies	41% ± 15%	Explore
basal cell	21 studies	41% ± 17%	Explore
memory B cell	20 studies	32% ± 7%	Explore
naive B cell	20 studies	30% ± 7%	Explore
dendritic cell	19 studies	38% ± 21%	Explore
epithelial cell	18 studies	36% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	17 studies	39% ± 11%	Explore
ciliated cell	17 studies	35% ± 17%	Explore
connective tissue cell	17 studies	33% ± 11%	Explore
mature NK T cell	16 studies	26% ± 7%	Explore
gamma-delta T cell	16 studies	30% ± 10%	Explore
myeloid cell	16 studies	43% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	27% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	34% ± 10%	Explore
capillary endothelial cell	15 studies	40% ± 14%	Explore
myofibroblast cell	15 studies	35% ± 9%	Explore
astrocyte	15 studies	33% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	30% ± 9%	Explore
microglial cell	14 studies	47% ± 15%	Explore
endothelial cell of vascular tree	14 studies	35% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	30% ± 9%	Explore
endothelial cell of artery	13 studies	42% ± 18%	Explore
vein endothelial cell	13 studies	40% ± 16%	Explore
mast cell	12 studies	25% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	29% ± 10%	Explore
oligodendrocyte	11 studies	30% ± 10%	Explore
mucosal invariant T cell	11 studies	27% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 7%	Explore
secretory cell	10 studies	40% ± 18%	Explore
leukocyte	10 studies	33% ± 11%	Explore
type I pneumocyte	9 studies	29% ± 6%	Explore
club cell	9 studies	28% ± 10%	Explore
platelet	9 studies	22% ± 4%	Explore
abnormal cell	9 studies	30% ± 10%	Explore
adipocyte	9 studies	26% ± 6%	Explore
alveolar macrophage	8 studies	25% ± 13%	Explore
erythrocyte	7 studies	34% ± 17%	Explore
plasmablast	7 studies	41% ± 24%	Explore
respiratory goblet cell	7 studies	29% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
mononuclear phagocyte	7 studies	40% ± 15%	Explore
mesothelial cell	7 studies	31% ± 15%	Explore
hematopoietic stem cell	7 studies	40% ± 10%	Explore
precursor B cell	7 studies	50% ± 17%	Explore
innate lymphoid cell	7 studies	30% ± 9%	Explore
T follicular helper cell	7 studies	23% ± 5%	Explore
plasma cell	6 studies	28% ± 12%	Explore
lymphocyte	6 studies	37% ± 10%	Explore
immature B cell	6 studies	49% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 11%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 10%	Explore
goblet cell	6 studies	35% ± 22%	Explore
CD4-positive helper T cell	5 studies	26% ± 11%	Explore
hematopoietic precursor cell	5 studies	48% ± 14%	Explore
progenitor cell	5 studies	27% ± 3%	Explore
glial cell	5 studies	29% ± 12%	Explore
pro-B cell	5 studies	62% ± 11%	Explore
type II pneumocyte	5 studies	23% ± 7%	Explore
adventitial cell	5 studies	25% ± 9%	Explore
cardiac muscle cell	5 studies	18% ± 2%	Explore
keratinocyte	5 studies	30% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	23% ± 3%	Explore
duct epithelial cell	4 studies	26% ± 10%	Explore
ionocyte	4 studies	33% ± 13%	Explore
squamous epithelial cell	4 studies	51% ± 20%	Explore
exhausted T cell	4 studies	34% ± 15%	Explore
transit amplifying cell	4 studies	28% ± 20%	Explore
Schwann cell	4 studies	31% ± 10%	Explore
melanocyte	4 studies	30% ± 6%	Explore
intermediate monocyte	4 studies	54% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 4%	Explore
myoepithelial cell	4 studies	34% ± 11%	Explore
neuron	4 studies	36% ± 15%	Explore
GABAergic neuron	4 studies	25% ± 8%	Explore
glutamatergic neuron	4 studies	35% ± 11%	Explore
neutrophil	4 studies	23% ± 6%	Explore
enteroendocrine cell	4 studies	34% ± 10%	Explore
T-helper 17 cell	4 studies	21% ± 2%	Explore
double negative thymocyte	4 studies	38% ± 12%	Explore
hillock cell	3 studies	28% ± 15%	Explore
pancreatic A cell	3 studies	33% ± 10%	Explore
type B pancreatic cell	3 studies	35% ± 13%	Explore
glomerular endothelial cell	3 studies	39% ± 11%	Explore
podocyte	3 studies	41% ± 14%	Explore
neural crest cell	3 studies	26% ± 5%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 4%	Explore
placental villous trophoblast	3 studies	41% ± 11%	Explore
megakaryocyte	3 studies	42% ± 8%	Explore
brush cell	3 studies	34% ± 17%	Explore
serous secreting cell	3 studies	25% ± 9%	Explore
tissue-resident macrophage	3 studies	30% ± 8%	Explore
germinal center B cell	3 studies	31% ± 1%	Explore
inflammatory macrophage	3 studies	28% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	34% ± 12%	Explore
muscle cell	3 studies	34% ± 12%	Explore
pancreatic ductal cell	3 studies	52% ± 11%	Explore
ependymal cell	3 studies	32% ± 15%	Explore
granulocyte	3 studies	30% ± 11%	Explore
enterocyte	3 studies	19% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 11%	Explore
T-helper 1 cell	3 studies	27% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	29% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	24% ± 2%	Explore
progenitor cell of mammary luminal epithelium	3 studies	26% ± 6%	Explore
mural cell	3 studies	39% ± 7%	Explore
mucus secreting cell	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	34% ± 14%	Explore
peripheral blood	18 studies	37% ± 14%	Explore
brain	14 studies	29% ± 14%	Explore
intestine	8 studies	28% ± 12%	Explore
kidney	7 studies	25% ± 7%	Explore
heart	5 studies	26% ± 4%	Explore
lymph node	5 studies	27% ± 6%	Explore
pancreas	4 studies	32% ± 14%	Explore
bone marrow	4 studies	36% ± 11%	Explore
uterus	4 studies	39% ± 14%	Explore
skin	4 studies	26% ± 8%	Explore
breast	4 studies	30% ± 5%	Explore
prostate	4 studies	25% ± 11%	Explore
liver	4 studies	38% ± 17%	Explore
adipose	4 studies	33% ± 6%	Explore
placenta	3 studies	39% ± 1%	Explore
esophagus	3 studies	46% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	17804.01	1445 / 1445	100%	169.67	183 / 183
prostate	100%	9542.13	245 / 245	100%	99.05	502 / 502
stomach	100%	9044.73	359 / 359	100%	104.32	286 / 286
intestine	100%	12644.71	966 / 966	100%	100.60	526 / 527
skin	100%	14170.35	1809 / 1809	100%	129.97	471 / 472
ovary	100%	13401.15	180 / 180	100%	126.03	429 / 430
lung	100%	13135.71	578 / 578	100%	123.97	1152 / 1155
breast	100%	13187.42	459 / 459	99%	115.87	1111 / 1118
thymus	100%	9493.25	652 / 653	100%	104.99	602 / 605
uterus	100%	14718.26	170 / 170	99%	119.67	454 / 459
kidney	100%	7111.49	89 / 89	98%	104.11	886 / 901
bladder	100%	13249.86	21 / 21	98%	86.02	493 / 504
pancreas	96%	5492.38	315 / 328	98%	85.25	175 / 178
brain	92%	4299.85	2440 / 2642	100%	99.20	705 / 705
adrenal gland	100%	9120.12	258 / 258	84%	38.93	194 / 230
liver	45%	1503.76	101 / 226	76%	30.49	310 / 406
adipose	100%	13620.29	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16564.01	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	113.25	29 / 29
spleen	100%	12616.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	210.70	45 / 45
ureter	0%	0	0 / 0	100%	33.03	1 / 1
peripheral blood	100%	13889.95	928 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	85.44	79 / 80
heart	99%	5641.82	850 / 861	0%	0	0 / 0
muscle	69%	2195.13	552 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001525	Biological process	angiogenesis
GO_0007188	Biological process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0006897	Biological process	endocytosis
GO_0072673	Biological process	lamellipodium morphogenesis
GO_0030048	Biological process	actin filament-based movement
GO_0030032	Biological process	lamellipodium assembly
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0098974	Biological process	postsynaptic actin cytoskeleton organization
GO_0035855	Biological process	megakaryocyte development
GO_0030036	Biological process	actin cytoskeleton organization
GO_0016601	Biological process	Rac protein signal transduction
GO_0001667	Biological process	ameboidal-type cell migration
GO_2000601	Biological process	positive regulation of Arp2/3 complex-mediated actin nucleation
GO_0051497	Biological process	negative regulation of stress fiber assembly
GO_0001726	Cellular component	ruffle
GO_0005769	Cellular component	early endosome
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005911	Cellular component	cell-cell junction
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0030027	Cellular component	lamellipodium
GO_0031209	Cellular component	SCAR complex
GO_0016323	Cellular component	basolateral plasma membrane
GO_0034237	Molecular function	protein kinase A regulatory subunit binding
GO_0045296	Molecular function	cadherin binding
GO_0071933	Molecular function	Arp2/3 complex binding
GO_0051018	Molecular function	protein kinase A binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	WASF2
Protein name	WASF2 protein Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)
Synonyms	WAVE2
Description	FUNCTION: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. .
Accessions	ENST00000618852.5 [Q9Y6W5-1] Q9Y6W5 ENST00000536657.1 [Q9Y6W5-2] Q05BU7

WASF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review