KCNQ3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
microglial cell	14 studies	69% ± 16%	Explore
glutamatergic neuron	11 studies	75% ± 16%	Explore
oligodendrocyte precursor cell	11 studies	32% ± 13%	Explore
GABAergic neuron	10 studies	65% ± 21%	Explore
astrocyte	9 studies	31% ± 16%	Explore
interneuron	6 studies	55% ± 28%	Explore
macrophage	5 studies	34% ± 13%	Explore
neuron	5 studies	44% ± 12%	Explore
type II pneumocyte	5 studies	29% ± 5%	Explore
endothelial cell	4 studies	44% ± 20%	Explore
retinal ganglion cell	4 studies	34% ± 14%	Explore
adipocyte	4 studies	23% ± 8%	Explore
GABAergic interneuron	3 studies	77% ± 2%	Explore
type I pneumocyte	3 studies	19% ± 3%	Explore
oligodendrocyte	3 studies	33% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	46% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	4615.20	2530 / 2642	98%	9.03	694 / 705
lung	77%	1098.93	446 / 578	60%	5.30	692 / 1155
breast	57%	451.53	262 / 459	64%	2.32	718 / 1118
thymus	41%	255.40	268 / 653	77%	8.01	467 / 605
kidney	30%	147.61	27 / 89	73%	2.36	661 / 901
pancreas	29%	229.44	95 / 328	55%	1.60	98 / 178
adrenal gland	20%	88.47	51 / 258	56%	5.15	128 / 230
adipose	69%	602.46	829 / 1204	0%	0	0 / 0
spleen	56%	235.22	135 / 241	0%	0	0 / 0
prostate	37%	170.00	91 / 245	15%	0.29	76 / 502
ovary	1%	4.06	2 / 180	51%	1.71	220 / 430
intestine	33%	135.27	320 / 966	14%	0.33	76 / 527
skin	36%	276.59	650 / 1809	8%	0.18	40 / 472
blood vessel	36%	147.73	480 / 1335	0%	0	0 / 0
esophagus	9%	34.59	137 / 1445	21%	0.49	38 / 183
stomach	8%	30.09	29 / 359	21%	0.65	60 / 286
uterus	7%	27.05	12 / 170	20%	0.57	90 / 459
bladder	10%	27.38	2 / 21	12%	0.63	62 / 504
tonsil	0%	0	0 / 0	16%	0.97	7 / 45
heart	13%	52.99	108 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.11	2 / 29
liver	0%	0	0 / 226	3%	0.08	14 / 406
eye	0%	0	0 / 0	3%	0.04	2 / 80
muscle	0%	0.46	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007605	Biological process	sensory perception of sound
GO_0010996	Biological process	response to auditory stimulus
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_1903701	Biological process	substantia propria of cornea development
GO_0006897	Biological process	endocytosis
GO_0016322	Biological process	neuron remodeling
GO_0099611	Biological process	regulation of action potential firing threshold
GO_0021675	Biological process	nerve development
GO_0099610	Biological process	action potential initiation
GO_0014070	Biological process	response to organic cyclic compound
GO_0098976	Biological process	excitatory chemical synaptic transmission
GO_0098977	Biological process	inhibitory chemical synaptic transmission
GO_0006605	Biological process	protein targeting
GO_0036343	Biological process	psychomotor behavior
GO_0071805	Biological process	potassium ion transmembrane transport
GO_0071277	Biological process	cellular response to calcium ion
GO_0060081	Biological process	membrane hyperpolarization
GO_0051402	Biological process	neuron apoptotic process
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0006887	Biological process	exocytosis
GO_0007268	Biological process	chemical synaptic transmission
GO_0019228	Biological process	neuronal action potential
GO_0051882	Biological process	mitochondrial depolarization
GO_0006606	Biological process	protein import into nucleus
GO_0097314	Biological process	apoptosome assembly
GO_0010467	Biological process	gene expression
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0043194	Cellular component	axon initial segment
GO_0009986	Cellular component	cell surface
GO_0045202	Cellular component	synapse
GO_0033268	Cellular component	node of Ranvier
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0005249	Molecular function	voltage-gated potassium channel activity
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KCNQ3
Protein name	Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3) Potassium voltage-gated channel subfamily Q member 3
Synonyms
Description	FUNCTION: Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation . .
Accessions	A0A1W2PRN8 ENST00000639496.1 A0A1W2PNZ2 ENST00000519445.5 ENST00000388996.10 [O43525-1] O43525 ENST00000639358.1 E7ET42 ENST00000521134.6 [O43525-2] ENST00000638588.1 A0A1W2PQ71

KCNQ3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review