Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 47 studies | 70% ± 23% | |
non-classical monocyte | 22 studies | 34% ± 11% | |
conventional dendritic cell | 15 studies | 38% ± 15% | |
microglial cell | 14 studies | 51% ± 31% | |
dendritic cell | 13 studies | 35% ± 25% | |
monocyte | 12 studies | 43% ± 23% | |
myeloid cell | 11 studies | 57% ± 24% | |
alveolar macrophage | 8 studies | 74% ± 27% | |
mononuclear phagocyte | 8 studies | 47% ± 20% | |
leukocyte | 7 studies | 41% ± 12% | |
classical monocyte | 4 studies | 33% ± 13% | |
endothelial cell | 3 studies | 44% ± 24% | |
tissue-resident macrophage | 3 studies | 74% ± 20% | |
intermediate monocyte | 3 studies | 26% ± 3% | |
inflammatory macrophage | 3 studies | 64% ± 23% | |
monocyte-derived dendritic cell | 3 studies | 45% ± 9% | |
endothelial cell of lymphatic vessel | 3 studies | 27% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 12282.62 | 574 / 578 | 90% | 435.52 | 1041 / 1155 |
breast | 92% | 3447.11 | 423 / 459 | 89% | 287.21 | 993 / 1118 |
adrenal gland | 98% | 6671.04 | 252 / 258 | 70% | 243.71 | 161 / 230 |
intestine | 96% | 4186.19 | 923 / 966 | 72% | 201.13 | 380 / 527 |
bladder | 95% | 2759.48 | 20 / 21 | 68% | 329.61 | 343 / 504 |
stomach | 76% | 2070.99 | 274 / 359 | 76% | 232.09 | 216 / 286 |
prostate | 84% | 2017.75 | 206 / 245 | 65% | 116.22 | 328 / 502 |
kidney | 57% | 2009.07 | 51 / 89 | 87% | 483.80 | 786 / 901 |
ovary | 59% | 1392.81 | 107 / 180 | 84% | 290.83 | 360 / 430 |
thymus | 65% | 1540.60 | 427 / 653 | 78% | 232.71 | 469 / 605 |
uterus | 61% | 1359.70 | 104 / 170 | 78% | 355.66 | 360 / 459 |
brain | 40% | 1076.89 | 1048 / 2642 | 92% | 511.10 | 651 / 705 |
esophagus | 69% | 2075.90 | 990 / 1445 | 59% | 144.48 | 108 / 183 |
pancreas | 36% | 559.02 | 119 / 328 | 90% | 414.85 | 161 / 178 |
liver | 49% | 1529.19 | 111 / 226 | 77% | 262.99 | 313 / 406 |
skin | 27% | 416.25 | 489 / 1809 | 88% | 627.96 | 413 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 2032.19 | 29 / 29 |
spleen | 100% | 44814.32 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 98% | 7834.42 | 1179 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 417.30 | 41 / 45 |
blood vessel | 86% | 4124.29 | 1143 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 71% | 263.64 | 57 / 80 |
heart | 63% | 1444.11 | 543 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 48% | 1521.11 | 445 / 929 | 0% | 0 | 0 / 0 |
muscle | 10% | 137.10 | 81 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0001774 | Biological process | microglial cell activation |
GO_0016322 | Biological process | neuron remodeling |
GO_0150062 | Biological process | complement-mediated synapse pruning |
GO_0045087 | Biological process | innate immune response |
GO_0048143 | Biological process | astrocyte activation |
GO_0150064 | Biological process | vertebrate eye-specific patterning |
GO_0006956 | Biological process | complement activation |
GO_0007267 | Biological process | cell-cell signaling |
GO_0006958 | Biological process | complement activation, classical pathway |
GO_0098883 | Biological process | synapse pruning |
GO_0050808 | Biological process | synapse organization |
GO_0005576 | Cellular component | extracellular region |
GO_0062167 | Cellular component | complement component C1q complex |
GO_0005581 | Cellular component | collagen trimer |
GO_0098794 | Cellular component | postsynapse |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0045202 | Cellular component | synapse |
GO_0005602 | Cellular component | complement component C1 complex |
GO_0001540 | Molecular function | amyloid-beta binding |
GO_0005515 | Molecular function | protein binding |
Gene name | C1QA |
Protein name | Complement C1q A chain Complement C1q subcomponent subunit A |
Synonyms | |
Description | FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. . |
Accessions | ENST00000438241.1 ENST00000695744.1 A0A8Q3SI08 ENST00000695738.1 ENST00000374642.8 ENST00000695740.1 ENST00000695741.1 X6RLJ0 A0A8Q3SI59 ENST00000438241.2 ENST00000695746.1 ENST00000402322.2 ENST00000695743.1 ENST00000695739.1 ENST00000695742.1 A0A8Q3SI63 A0A8Q3SI41 A0A8Q3SI02 ENST00000695745.1 P02745 |