C1QA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001774Biological processmicroglial cell activation
GO_0016322Biological processneuron remodeling
GO_0150062Biological processcomplement-mediated synapse pruning
GO_0045087Biological processinnate immune response
GO_0048143Biological processastrocyte activation
GO_0150064Biological processvertebrate eye-specific patterning
GO_0006956Biological processcomplement activation
GO_0007267Biological processcell-cell signaling
GO_0006958Biological processcomplement activation, classical pathway
GO_0098883Biological processsynapse pruning
GO_0050808Biological processsynapse organization
GO_0005576Cellular componentextracellular region
GO_0062167Cellular componentcomplement component C1q complex
GO_0005581Cellular componentcollagen trimer
GO_0098794Cellular componentpostsynapse
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0045202Cellular componentsynapse
GO_0005602Cellular componentcomplement component C1 complex
GO_0001540Molecular functionamyloid-beta binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameC1QA
Protein nameComplement C1q A chain
Complement C1q subcomponent subunit A
Synonyms
DescriptionFUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

FUNCTION: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. .

AccessionsENST00000438241.1
ENST00000695744.1
A0A8Q3SI08
ENST00000695738.1
ENST00000374642.8
ENST00000695740.1
ENST00000695741.1
X6RLJ0
A0A8Q3SI59
ENST00000438241.2
ENST00000695746.1
ENST00000402322.2
ENST00000695743.1
ENST00000695739.1
ENST00000695742.1
A0A8Q3SI63
A0A8Q3SI41
A0A8Q3SI02
ENST00000695745.1
P02745