ACAN | OmnibusX

Name	Number of supported studies	Average coverage
chondrocyte	4 studies	58% ± 23%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of ACAN at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	67%	197.75	60 / 89	65%	9.32	586 / 901
bladder	71%	136.57	15 / 21	50%	1.70	251 / 504
brain	62%	101.18	1629 / 2642	49%	3.64	348 / 705
stomach	23%	51.86	82 / 359	87%	5.13	248 / 286
lung	69%	312.00	401 / 578	37%	1.07	430 / 1155
intestine	23%	37.77	226 / 966	83%	3.30	435 / 527
blood vessel	99%	8513.79	1322 / 1335	0%	0	0 / 0
thymus	68%	132.05	445 / 653	29%	0.76	176 / 605
adrenal gland	39%	62.00	101 / 258	47%	3.76	108 / 230
esophagus	17%	28.85	249 / 1445	63%	2.87	116 / 183
uterus	48%	116.81	82 / 170	32%	6.10	148 / 459
breast	31%	57.31	142 / 459	47%	5.58	528 / 1118
skin	42%	147.53	759 / 1809	36%	3.50	168 / 472
prostate	56%	171.30	136 / 245	18%	0.45	92 / 502
ovary	53%	122.01	96 / 180	15%	0.43	66 / 430
pancreas	12%	20.42	39 / 328	52%	1.32	92 / 178
adipose	58%	197.52	696 / 1204	0%	0	0 / 0
spleen	43%	48.88	104 / 241	0%	0	0 / 0
heart	36%	57.56	308 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	18%	0.58	14 / 80
liver	1%	1.38	2 / 226	17%	0.53	67 / 406
muscle	16%	24.52	129 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	16%	0.26	7 / 45
lymph node	0%	0	0 / 0	3%	0.03	1 / 29
peripheral blood	0%	0.07	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_0010001	Biological process	glial cell differentiation
GO_0007155	Biological process	cell adhesion
GO_0006508	Biological process	proteolysis
GO_0007417	Biological process	central nervous system development
GO_0001501	Biological process	skeletal system development
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005796	Cellular component	Golgi lumen
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0045202	Cellular component	synapse
GO_0043202	Cellular component	lysosomal lumen
GO_0072534	Cellular component	perineuronal net
GO_0005201	Molecular function	extracellular matrix structural constituent
GO_0030246	Molecular function	carbohydrate binding
GO_0030021	Molecular function	extracellular matrix structural constituent conferring compression resistance
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding
GO_0005540	Molecular function	hyaluronic acid binding

Gene name	ACAN
Protein name	Aggrecan Aggrecan core protein (Cartilage-specific proteoglycan core protein) Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]
Synonyms	AGC1 MSK16 CSPG1
Description	FUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Accessions	H0YK70 ENST00000559004.5 [P16112-2] P16112 A0A5K1VW97 Q6PID9 ENST00000558704.1 ENST00000439576.7 [P16112-1] ENST00000561243.7 ENST00000558207.5 ENST00000352105.11 [P16112-3] H0YMF1 ENST00000560601.4

ACAN report