SARM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070585Biological processprotein localization to mitochondrion
GO_0009749Biological processresponse to glucose
GO_0048814Biological processregulation of dendrite morphogenesis
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0048678Biological processresponse to axon injury
GO_0043523Biological processregulation of neuron apoptotic process
GO_0019677Biological processNAD catabolic process
GO_0030154Biological processcell differentiation
GO_0050877Biological processnervous system process
GO_0007399Biological processnervous system development
GO_0034128Biological processnegative regulation of MyD88-independent toll-like receptor signaling pathway
GO_0005874Cellular componentmicrotubule
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030424Cellular componentaxon
GO_0003953Molecular functionNAD+ nucleosidase activity
GO_0050135Molecular functionNADP+ nucleosidase activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameSARM1
Protein nameNAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR)
NAD(+) hydrolase SARM1 (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (Sterile alpha and TIR motif-containing protein 1)
NAD(+) hydrolase SARM1 (NADP(+) hydrolase SARM1) (Sterile alpha and TIR motif-containing protein 1)
Sterile alpha and TIR motif containing 1
SynonymsKIAA0524
SAMD2
SARM
DescriptionFUNCTION: NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism . Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site . Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction . Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules . Can activate neuronal cell death in response to stress . Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 . .

AccessionsJ3QRE0
ENST00000585482.6 [Q6SZW1-1]
Q6SZW1
J3KRZ6
Q05B42
ENST00000582323.1
J3KSG7
ENST00000578128.5
ENST00000579593.1
Q0D2N8