TDRD1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TDRD1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TDRD1 at tissue level.

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0007283Biological processspermatogenesis
GO_0030719Biological processP granule organization
GO_0007281Biological processgerm cell development
GO_0141007Biological processsiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0034587Biological processpiRNA processing
GO_0071546Cellular componentpi-body
GO_0033391Cellular componentchromatoid body
GO_1990904Cellular componentribonucleoprotein complex
GO_0045202Cellular componentsynapse
GO_0043186Cellular componentP granule
GO_0005737Cellular componentcytoplasm
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameTDRD1
Protein nameTudor domain containing 1
Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1)
Synonyms
DescriptionFUNCTION: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). .

AccessionsENST00000369280.1
ENST00000695399.1 [Q9BXT4-1]
ENST00000251864.7 [Q9BXT4-3]
H9KV62
Q9BXT4
H9KV63
ENST00000369282.5