Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 31% ± 17% | |
| GABAergic neuron | 6 studies | 41% ± 21% | |
| interneuron | 5 studies | 33% ± 18% | |
| glutamatergic neuron | 5 studies | 34% ± 15% | |
| astrocyte | 4 studies | 25% ± 3% | |
| GABAergic interneuron | 3 studies | 26% ± 7% | |
| neuron | 3 studies | 22% ± 2% | |
| retinal pigment epithelial cell | 3 studies | 33% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 33% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 2401.32 | 2628 / 2642 | 99% | 6.56 | 698 / 705 |
| thymus | 100% | 8185.30 | 652 / 653 | 84% | 5.96 | 507 / 605 |
| lung | 82% | 789.80 | 475 / 578 | 85% | 3.94 | 981 / 1155 |
| skin | 63% | 587.92 | 1138 / 1809 | 91% | 4.01 | 428 / 472 |
| esophagus | 46% | 706.18 | 665 / 1445 | 95% | 5.76 | 173 / 183 |
| uterus | 58% | 326.99 | 98 / 170 | 81% | 2.74 | 372 / 459 |
| intestine | 35% | 267.69 | 338 / 966 | 91% | 3.33 | 481 / 527 |
| ovary | 28% | 182.18 | 51 / 180 | 89% | 3.82 | 384 / 430 |
| breast | 54% | 305.85 | 248 / 459 | 60% | 1.85 | 670 / 1118 |
| bladder | 38% | 222.24 | 8 / 21 | 72% | 2.59 | 364 / 504 |
| stomach | 18% | 116.75 | 66 / 359 | 85% | 3.47 | 244 / 286 |
| spleen | 99% | 782.51 | 238 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 2.56 | 39 / 45 |
| adrenal gland | 47% | 303.77 | 122 / 258 | 38% | 1.05 | 87 / 230 |
| blood vessel | 72% | 538.07 | 955 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 6% | 37.16 | 21 / 328 | 61% | 1.48 | 108 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 62% | 2.23 | 18 / 29 |
| prostate | 47% | 244.60 | 115 / 245 | 13% | 0.20 | 63 / 502 |
| adipose | 53% | 326.30 | 642 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 38% | 249.01 | 34 / 89 | 12% | 0.28 | 105 / 901 |
| peripheral blood | 39% | 935.70 | 362 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 30% | 0.69 | 24 / 80 |
| liver | 1% | 8.93 | 3 / 226 | 8% | 0.20 | 31 / 406 |
| heart | 9% | 48.72 | 75 / 861 | 0% | 0 | 0 / 0 |
| muscle | 6% | 32.02 | 48 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019221 | Biological process | cytokine-mediated signaling pathway |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0006897 | Biological process | endocytosis |
| GO_0061003 | Biological process | positive regulation of dendritic spine morphogenesis |
| GO_0048813 | Biological process | dendrite morphogenesis |
| GO_0021517 | Biological process | ventral spinal cord development |
| GO_0007165 | Biological process | signal transduction |
| GO_0021819 | Biological process | layer formation in cerebral cortex |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0045088 | Biological process | regulation of innate immune response |
| GO_0001523 | Biological process | retinoid metabolic process |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_1900006 | Biological process | positive regulation of dendrite development |
| GO_0038026 | Biological process | reelin-mediated signaling pathway |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0071397 | Biological process | cellular response to cholesterol |
| GO_0006508 | Biological process | proteolysis |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0021541 | Biological process | ammon gyrus development |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0005615 | Cellular component | extracellular space |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0030425 | Cellular component | dendrite |
| GO_0009986 | Cellular component | cell surface |
| GO_0045202 | Cellular component | synapse |
| GO_0030424 | Cellular component | axon |
| GO_0005875 | Cellular component | microtubule associated complex |
| GO_0005901 | Cellular component | caveola |
| GO_0038025 | Molecular function | reelin receptor activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0038024 | Molecular function | cargo receptor activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0034185 | Molecular function | apolipoprotein binding |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0005041 | Molecular function | low-density lipoprotein particle receptor activity |
| GO_0030229 | Molecular function | very-low-density lipoprotein particle receptor activity |
| GO_0008035 | Molecular function | high-density lipoprotein particle binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0019894 | Molecular function | kinesin binding |
| Gene name | LRP8 |
| Protein name | LDL receptor related protein 8 Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) |
| Synonyms | APOER2 |
| Description | FUNCTION: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands . LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for Semliki Forest virus. . |
| Accessions | A0A590UKB5 ENST00000653169.1 ENST00000667377.1 A0A590UJT0 ENST00000480045.6 ENST00000662604.1 H0YCA4 ENST00000656486.1 A0A590UJ57 ENST00000347547.7 [Q14114-4] ENST00000658277.1 A0A590UJH5 ENST00000529670.6 A0A590UJF9 A0A590UJV3 A0A590UK97 Q14114 ENST00000654947.1 ENST00000661457.1 ENST00000354412.7 [Q14114-2] A0A590UJQ4 H0YEA5 ENST00000657895.1 ENST00000653217.1 ENST00000306052.12 [Q14114-1] ENST00000668448.1 A0A590UJJ8 A0A590UK53 ENST00000668071.1 ENST00000662198.1 E9PP15 ENST00000475501.2 ENST00000662802.1 ENST00000481431.2 A0A590UKB1 ENST00000657047.1 ENST00000659993.1 A0A590UJJ9 ENST00000465675.6 ENST00000653810.1 A0A590UJ30 ENST00000460214.6 A0A590UK45 A0A590UJ98 H0YEV6 E9PKG2 ENST00000371454.6 [Q14114-3] A0A590UJ39 A0A590UK84 |
