Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 6 studies | 46% ± 17% | |
| glutamatergic neuron | 5 studies | 31% ± 14% | |
| GABAergic interneuron | 3 studies | 37% ± 5% | |
| neuron | 3 studies | 17% ± 3% | |
| interneuron | 3 studies | 54% ± 20% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 33% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 96% | 132.25 | 236 / 245 | 65% | 12.36 | 328 / 502 |
| brain | 89% | 336.13 | 2363 / 2642 | 58% | 5.44 | 410 / 705 |
| intestine | 98% | 84.66 | 944 / 966 | 5% | 0.09 | 27 / 527 |
| breast | 92% | 95.16 | 422 / 459 | 9% | 0.14 | 97 / 1118 |
| spleen | 100% | 134.29 | 240 / 241 | 0% | 0 | 0 / 0 |
| skin | 82% | 52.58 | 1477 / 1809 | 15% | 0.28 | 73 / 472 |
| esophagus | 94% | 67.14 | 1356 / 1445 | 2% | 0.14 | 4 / 183 |
| bladder | 90% | 39.19 | 19 / 21 | 5% | 0.12 | 24 / 504 |
| ovary | 94% | 104.51 | 170 / 180 | 1% | 0.01 | 3 / 430 |
| uterus | 89% | 52.18 | 151 / 170 | 6% | 0.13 | 27 / 459 |
| adrenal gland | 86% | 39.53 | 221 / 258 | 7% | 0.34 | 16 / 230 |
| blood vessel | 91% | 52.20 | 1220 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 91% | 57.35 | 591 / 653 | 1% | 0.01 | 5 / 605 |
| liver | 90% | 45.33 | 204 / 226 | 1% | 0.01 | 3 / 406 |
| lung | 83% | 44.49 | 479 / 578 | 8% | 0.15 | 91 / 1155 |
| kidney | 81% | 42.63 | 72 / 89 | 5% | 0.08 | 45 / 901 |
| adipose | 84% | 48.00 | 1010 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 75% | 29.53 | 268 / 359 | 8% | 0.15 | 23 / 286 |
| heart | 82% | 94.86 | 708 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 70% | 38.59 | 650 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 66% | 23.23 | 216 / 328 | 2% | 0.23 | 3 / 178 |
| muscle | 54% | 17.14 | 435 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 1.24 | 14 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 0.14 | 4 / 45 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0061000 | Biological process | negative regulation of dendritic spine development |
| GO_0035235 | Biological process | ionotropic glutamate receptor signaling pathway |
| GO_0045471 | Biological process | response to ethanol |
| GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0060134 | Biological process | prepulse inhibition |
| GO_0016358 | Biological process | dendrite development |
| GO_0048511 | Biological process | rhythmic process |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0035249 | Biological process | synaptic transmission, glutamatergic |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098839 | Cellular component | postsynaptic density membrane |
| GO_0098793 | Cellular component | presynapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0045202 | Cellular component | synapse |
| GO_0017146 | Cellular component | NMDA selective glutamate receptor complex |
| GO_0008066 | Molecular function | glutamate receptor activity |
| GO_0051721 | Molecular function | protein phosphatase 2A binding |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004972 | Molecular function | NMDA glutamate receptor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0016594 | Molecular function | glycine binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005262 | Molecular function | calcium channel activity |
| Gene name | GRIN3A |
| Protein name | Glutamate receptor Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L) |
| Synonyms | KIAA1973 |
| Description | FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . |
| Accessions | ENST00000361820.6 Q8TCU5 A2RUE7 |
