QKI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035886Biological processvascular associated smooth muscle cell differentiation
GO_1990764Biological processmyofibroblast contraction
GO_0006397Biological processmRNA processing
GO_0042552Biological processmyelination
GO_0051028Biological processmRNA transport
GO_0010628Biological processpositive regulation of gene expression
GO_1905869Biological processnegative regulation of 3'-UTR-mediated mRNA stabilization
GO_0001570Biological processvasculogenesis
GO_0008380Biological processRNA splicing
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_0014004Biological processmicroglia differentiation
GO_0048710Biological processregulation of astrocyte differentiation
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0008298Biological processintracellular mRNA localization
GO_0010717Biological processregulation of epithelial to mesenchymal transition
GO_0007286Biological processspermatid development
GO_0045649Biological processregulation of macrophage differentiation
GO_0017148Biological processnegative regulation of translation
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0160089Molecular functioninternal N(7)-methylguanine-containing RNA reader activity
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameQKI
Protein nameKH domain-containing RNA-binding protein QKI (Protein quaking) (Hqk) (HqkI)
QKI, KH domain containing RNA binding
SynonymsHKQ
DescriptionFUNCTION: RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation . Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development . Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence . Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) . Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons . CircRNAs are produced by back-splicing circularization of pre-mRNAs . Plays a central role in myelinization via 3 distinct mechanisms . First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation (By similarity). Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA (By similarity). Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation (By similarity). Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes . Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts (By similarity). Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1 (By similarity). Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development . In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity). .; FUNCTION: [Isoform QKI5]: Nuclear isoform that acts as an indirect regulator of mRNA splicing (By similarity). Regulates mRNA splicing of MAG pre-mRNA by inhibiting translation of HNRNPA1 mRNA, thereby preventing MAG exon 12 alternative splicing (By similarity). Involved in oligodendrocyte differentiation by promoting stabilization of SIRT2 mRNA (By similarity). Acts as a negative regulator of the interferon response by binding to MAVS mRNA, downregulating its expression . Also inhibits the interferon response by binding to fibrinectin FN1 pre-mRNA, repressing EDA exon inclusion in FN1 . Delays macrophage differentiation by binding to CSF1R mRNA, promoting its degradation . In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2, promoting SREBF2/SREBP2-dependent cholesterol biosynthesis (By similarity). SREBF2/SREBP2-dependent cholesterol biosynthesis participates to myelinization and is required for eye lens transparency (By similarity). .; FUNCTION: [Isoform QKI6]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) . Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation . Acts as a translational repressor for HNRNPA1 and GLI1 (By similarity). Translation inhibition of HNRNPA1 during oligodendrocyte differentiation prevents inclusion of exon 12 in MAG pre-mRNA splicing (By similarity). Involved in astrocyte differentiation by regulating translation of target mRNAs (By similarity). .; FUNCTION: [Isoform QKI7]: Cytosolic isoform that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G) . Interaction with G3BP1 promotes localization of m7G-containing mRNAs into stress granules in response to stress, thereby suppressing their translation . Acts as a negative regulator of angiogenesis by binding to mRNAs encoding CDH5, NLGN1 and TNFAIP6, promoting their degradation . Can also induce apoptosis in the cytoplasm (By similarity). Heterodimerization with other isoforms results in nuclear translocation of isoform QKI7 and suppression of apoptosis (By similarity). Also binds some microRNAs: promotes stabilitation of miR-122 by mediating recruitment of poly(A) RNA polymerase TENT2, leading to 3' adenylation and stabilization of miR-122 . .

AccessionsENST00000545607.5
F5GXS8
ENST00000424802.7 [Q96PU8-5]
ENST00000544436.5
ENST00000275262.11 [Q96PU8-6]
ENST00000392127.6 [Q96PU8-8]
Q96PU8
ENST00000361195.6 [Q96PU8-3]
F5GYT7
H0YG47
ENST00000545346.1
ENST00000537124.5
ENST00000361758.8 [Q96PU8-9]
ENST00000537041.5
ENST00000544361.1
ENST00000544823.5
ENST00000361752.8 [Q96PU8-1]
ENST00000453779.6 [Q96PU8-9]
F5GYM3
H0YGD6
H0YFB7
F5H5U6
ENST00000537883.5
F5H8C8