EIF2S2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	39% ± 16%	Explore
fibroblast	35 studies	31% ± 13%	Explore
B cell	32 studies	29% ± 9%	Explore
natural killer cell	32 studies	29% ± 8%	Explore
macrophage	30 studies	33% ± 12%	Explore
CD8-positive, alpha-beta T cell	30 studies	29% ± 12%	Explore
CD4-positive, alpha-beta T cell	29 studies	33% ± 13%	Explore
T cell	28 studies	31% ± 9%	Explore
pericyte	27 studies	31% ± 11%	Explore
smooth muscle cell	24 studies	30% ± 8%	Explore
conventional dendritic cell	24 studies	36% ± 13%	Explore
classical monocyte	22 studies	33% ± 11%	Explore
regulatory T cell	22 studies	31% ± 11%	Explore
non-classical monocyte	21 studies	33% ± 12%	Explore
epithelial cell	21 studies	41% ± 19%	Explore
basal cell	20 studies	37% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	37% ± 14%	Explore
monocyte	18 studies	34% ± 13%	Explore
endothelial cell of lymphatic vessel	18 studies	41% ± 14%	Explore
plasma cell	18 studies	40% ± 15%	Explore
memory B cell	18 studies	27% ± 8%	Explore
gamma-delta T cell	17 studies	30% ± 14%	Explore
mast cell	16 studies	28% ± 11%	Explore
dendritic cell	15 studies	35% ± 23%	Explore
ciliated cell	15 studies	45% ± 16%	Explore
naive B cell	15 studies	26% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	29% ± 9%	Explore
mature NK T cell	15 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	24% ± 6%	Explore
connective tissue cell	14 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	30% ± 9%	Explore
myofibroblast cell	13 studies	30% ± 10%	Explore
endothelial cell of vascular tree	13 studies	41% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	25% ± 7%	Explore
capillary endothelial cell	12 studies	34% ± 10%	Explore
vein endothelial cell	12 studies	37% ± 11%	Explore
mucosal invariant T cell	12 studies	23% ± 5%	Explore
plasmablast	11 studies	49% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 9%	Explore
secretory cell	11 studies	39% ± 14%	Explore
myeloid cell	11 studies	37% ± 15%	Explore
type I pneumocyte	10 studies	33% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 10%	Explore
abnormal cell	10 studies	35% ± 11%	Explore
endothelial cell of artery	10 studies	33% ± 9%	Explore
type II pneumocyte	9 studies	40% ± 19%	Explore
leukocyte	9 studies	31% ± 12%	Explore
goblet cell	9 studies	32% ± 11%	Explore
club cell	8 studies	32% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	29% ± 6%	Explore
progenitor cell	8 studies	35% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	38% ± 17%	Explore
neuron	7 studies	29% ± 14%	Explore
mesothelial cell	7 studies	30% ± 15%	Explore
precursor B cell	7 studies	35% ± 17%	Explore
microglial cell	7 studies	28% ± 12%	Explore
T follicular helper cell	7 studies	24% ± 3%	Explore
alveolar macrophage	6 studies	35% ± 10%	Explore
hematopoietic precursor cell	6 studies	42% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	36% ± 12%	Explore
mononuclear phagocyte	6 studies	33% ± 15%	Explore
epithelial cell of proximal tubule	6 studies	25% ± 5%	Explore
kidney loop of Henle epithelial cell	6 studies	25% ± 7%	Explore
transit amplifying cell	6 studies	33% ± 11%	Explore
innate lymphoid cell	6 studies	30% ± 4%	Explore
astrocyte	6 studies	27% ± 12%	Explore
erythrocyte	6 studies	39% ± 21%	Explore
oligodendrocyte	6 studies	25% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	36% ± 10%	Explore
ionocyte	5 studies	26% ± 9%	Explore
respiratory goblet cell	5 studies	30% ± 16%	Explore
enterocyte	5 studies	21% ± 5%	Explore
IgA plasma cell	5 studies	25% ± 7%	Explore
IgG plasma cell	5 studies	27% ± 6%	Explore
erythroblast	5 studies	46% ± 24%	Explore
hematopoietic stem cell	5 studies	42% ± 21%	Explore
pro-B cell	5 studies	34% ± 10%	Explore
deuterosomal cell	4 studies	57% ± 15%	Explore
pancreatic A cell	4 studies	53% ± 12%	Explore
type B pancreatic cell	4 studies	48% ± 14%	Explore
exhausted T cell	4 studies	37% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	33% ± 9%	Explore
enteroendocrine cell	4 studies	40% ± 11%	Explore
retinal ganglion cell	4 studies	64% ± 26%	Explore
immature B cell	4 studies	24% ± 7%	Explore
retinal rod cell	4 studies	27% ± 13%	Explore
adventitial cell	4 studies	24% ± 6%	Explore
neutrophil	4 studies	20% ± 4%	Explore
CD4-positive helper T cell	4 studies	27% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	44% ± 11%	Explore
GABAergic neuron	4 studies	27% ± 11%	Explore
glutamatergic neuron	4 studies	37% ± 16%	Explore
hepatocyte	4 studies	53% ± 21%	Explore
T-helper 17 cell	4 studies	39% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 8%	Explore
double negative thymocyte	4 studies	40% ± 19%	Explore
oligodendrocyte precursor cell	4 studies	26% ± 5%	Explore
duct epithelial cell	3 studies	24% ± 2%	Explore
pancreatic D cell	3 studies	53% ± 13%	Explore
glomerular endothelial cell	3 studies	22% ± 4%	Explore
intestinal crypt stem cell	3 studies	31% ± 9%	Explore
neural crest cell	3 studies	31% ± 4%	Explore
extravillous trophoblast	3 studies	73% ± 10%	Explore
placental villous trophoblast	3 studies	90% ± 7%	Explore
lymphocyte	3 studies	46% ± 9%	Explore
megakaryocyte	3 studies	36% ± 17%	Explore
brush cell	3 studies	33% ± 21%	Explore
neuroendocrine cell	3 studies	42% ± 8%	Explore
amacrine cell	3 studies	36% ± 19%	Explore
retina horizontal cell	3 studies	38% ± 15%	Explore
retinal cone cell	3 studies	42% ± 20%	Explore
mucus secreting cell	3 studies	30% ± 10%	Explore
serous secreting cell	3 studies	30% ± 7%	Explore
adipocyte	3 studies	18% ± 2%	Explore
intraepithelial lymphocyte	3 studies	36% ± 13%	Explore
Mueller cell	3 studies	23% ± 2%	Explore
germinal center B cell	3 studies	34% ± 5%	Explore
intermediate monocyte	3 studies	43% ± 20%	Explore
granulocyte	3 studies	36% ± 14%	Explore
luminal cell of prostate epithelium	3 studies	29% ± 7%	Explore
acinar cell	3 studies	45% ± 26%	Explore
pancreatic ductal cell	3 studies	57% ± 16%	Explore
glial cell	3 studies	33% ± 16%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 15%	Explore
keratinocyte	3 studies	31% ± 6%	Explore
T-helper 1 cell	3 studies	39% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	30% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	30% ± 11%	Explore
lung	17 studies	38% ± 11%	Explore
intestine	11 studies	26% ± 11%	Explore
brain	10 studies	27% ± 9%	Explore
kidney	8 studies	28% ± 8%	Explore
eye	8 studies	26% ± 12%	Explore
liver	7 studies	40% ± 20%	Explore
lymph node	6 studies	32% ± 11%	Explore
bone marrow	6 studies	30% ± 15%	Explore
uterus	5 studies	37% ± 19%	Explore
pancreas	4 studies	50% ± 15%	Explore
prostate	4 studies	37% ± 14%	Explore
breast	4 studies	32% ± 8%	Explore
placenta	3 studies	71% ± 2%	Explore
adrenal gland	3 studies	27% ± 4%	Explore
skin	3 studies	23% ± 1%	Explore
thymus	3 studies	43% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	5066.05	21 / 21	100%	168.88	504 / 504
esophagus	100%	5039.62	1445 / 1445	100%	153.80	183 / 183
lung	100%	5462.22	578 / 578	100%	148.06	1155 / 1155
ovary	100%	3425.79	180 / 180	100%	142.51	430 / 430
pancreas	100%	3283.92	328 / 328	100%	118.68	178 / 178
stomach	100%	4273.94	359 / 359	100%	191.58	286 / 286
uterus	100%	3793.55	170 / 170	100%	172.87	459 / 459
breast	100%	4842.77	459 / 459	100%	136.37	1116 / 1118
intestine	100%	4588.94	966 / 966	100%	185.65	526 / 527
prostate	100%	3932.69	245 / 245	100%	107.91	501 / 502
brain	100%	3069.16	2630 / 2642	100%	103.09	705 / 705
thymus	100%	3922.31	653 / 653	100%	100.41	602 / 605
skin	100%	6508.30	1808 / 1809	99%	137.76	469 / 472
liver	100%	3051.54	225 / 226	100%	86.91	404 / 406
kidney	100%	3894.82	89 / 89	98%	73.26	883 / 901
adrenal gland	100%	5253.23	258 / 258	98%	92.20	225 / 230
adipose	100%	5370.26	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	160.64	29 / 29
muscle	100%	6379.78	803 / 803	0%	0	0 / 0
spleen	100%	4287.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	183.04	45 / 45
ureter	0%	0	0 / 0	100%	67.56	1 / 1
blood vessel	100%	4729.87	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	96%	76.64	77 / 80
heart	96%	3221.95	827 / 861	0%	0	0 / 0
peripheral blood	92%	3921.94	854 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008584	Biological process	male gonad development
GO_0002183	Biological process	cytoplasmic translational initiation
GO_0001731	Biological process	formation of translation preinitiation complex
GO_0002176	Biological process	male germ cell proliferation
GO_0006413	Biological process	translational initiation
GO_0001701	Biological process	in utero embryonic development
GO_0005850	Cellular component	eukaryotic translation initiation factor 2 complex
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003743	Molecular function	translation initiation factor activity
GO_0008135	Molecular function	translation factor activity, RNA binding
GO_0031369	Molecular function	translation initiation factor binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	EIF2S2
Protein name	eIF2S2 protein Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF2-beta)
Synonyms	hCG_2018881 EIF2B
Description	FUNCTION: Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA . This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). .
Accessions	Q3B7I9 ENST00000374980.3 B5BU01 Q6IBR8 P20042

EIF2S2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review