GRID2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	15 studies	51% ± 18%	Explore
oligodendrocyte precursor cell	15 studies	83% ± 21%	Explore
oligodendrocyte	14 studies	40% ± 18%	Explore
microglial cell	14 studies	40% ± 17%	Explore
glutamatergic neuron	13 studies	59% ± 22%	Explore
GABAergic neuron	11 studies	61% ± 20%	Explore
interneuron	6 studies	61% ± 17%	Explore
Mueller cell	6 studies	70% ± 22%	Explore
endothelial cell	5 studies	49% ± 18%	Explore
amacrine cell	5 studies	37% ± 26%	Explore
retinal bipolar neuron	5 studies	43% ± 28%	Explore
neuron	4 studies	35% ± 12%	Explore
granule cell	4 studies	56% ± 28%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	71% ± 14%	Explore
GABAergic interneuron	3 studies	53% ± 17%	Explore
GABAergic amacrine cell	3 studies	48% ± 11%	Explore
OFF-bipolar cell	3 studies	56% ± 29%	Explore
glycinergic amacrine cell	3 studies	56% ± 16%	Explore
rod bipolar cell	3 studies	83% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	51% ± 17%	Explore
eye	6 studies	28% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	763.87	2631 / 2642	89%	8.91	628 / 705
adrenal gland	75%	152.21	193 / 258	42%	1.70	97 / 230
ovary	56%	92.78	100 / 180	13%	0.34	56 / 430
bladder	14%	16.19	3 / 21	1%	0.04	7 / 504
stomach	13%	17.84	48 / 359	1%	0.02	4 / 286
blood vessel	11%	13.15	146 / 1335	0%	0	0 / 0
breast	7%	9.66	33 / 459	2%	0.07	18 / 1118
heart	8%	7.32	65 / 861	0%	0	0 / 0
prostate	4%	3.38	10 / 245	2%	0.07	12 / 502
skin	0%	0.21	4 / 1809	6%	0.22	28 / 472
lung	4%	4.90	26 / 578	1%	0.03	14 / 1155
uterus	0%	0	0 / 170	4%	0.12	19 / 459
intestine	2%	1.86	21 / 966	1%	0.01	3 / 527
esophagus	0%	0.16	1 / 1445	2%	0.10	4 / 183
kidney	0%	0	0 / 89	2%	0.05	19 / 901
eye	0%	0	0 / 0	1%	0.04	1 / 80
pancreas	0%	0	0 / 328	1%	0.07	1 / 178
liver	0%	0.30	1 / 226	0%	0	0 / 406
adipose	0%	0.31	5 / 1204	0%	0	0 / 0
thymus	0%	0.21	1 / 653	0%	0.00	1 / 605
muscle	0%	0.28	2 / 803	0%	0	0 / 0
peripheral blood	0%	0.07	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_1905606	Biological process	regulation of presynapse assembly
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_1900454	Biological process	positive regulation of long-term synaptic depression
GO_1904861	Biological process	excitatory synapse assembly
GO_0043523	Biological process	regulation of neuron apoptotic process
GO_0010975	Biological process	regulation of neuron projection development
GO_0008104	Biological process	protein localization
GO_0021707	Biological process	cerebellar granule cell differentiation
GO_0060134	Biological process	prepulse inhibition
GO_0007215	Biological process	glutamate receptor signaling pathway
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0099151	Biological process	regulation of postsynaptic density assembly
GO_0035249	Biological process	synaptic transmission, glutamatergic
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0045202	Cellular component	synapse
GO_0098688	Cellular component	parallel fiber to Purkinje cell synapse
GO_0008328	Cellular component	ionotropic glutamate receptor complex
GO_0008066	Molecular function	glutamate receptor activity
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0042802	Molecular function	identical protein binding
GO_0030165	Molecular function	PDZ domain binding
GO_0097110	Molecular function	scaffold protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GRID2
Protein name	Glutamate receptor Glutamate ionotropic receptor delta type subunit 2 Uncharacterized protein GRID2 Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit)
Synonyms	GLURD2
Description	FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex . . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. . FUNCTION: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. .
Accessions	ENST00000512631.1 A0A1B0GW49 A0A087X043 Q4W5B7 Q4W5L9 Q4W5F4 D6R976 O43424 Q4W5S4 ENST00000502699.5 D6R9W8 ENST00000282020.9 [O43424-1] ENST00000611049.4 ENST00000510992.5 [O43424-2] ENST00000637838.1

GRID2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review