RPL13A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006412Biological processtranslation
GO_0002181Biological processcytoplasmic translation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0060425Biological processlung morphogenesis
GO_0042592Biological processhomeostatic process
GO_1901194Biological processnegative regulation of formation of translation preinitiation complex
GO_0017148Biological processnegative regulation of translation
GO_0048246Biological processmacrophage chemotaxis
GO_0071346Biological processcellular response to type II interferon
GO_0015934Cellular componentlarge ribosomal subunit
GO_0005730Cellular componentnucleolus
GO_0097452Cellular componentGAIT complex
GO_0022626Cellular componentcytosolic ribosome
GO_0005840Cellular componentribosome
GO_0016020Cellular componentmembrane
GO_0022625Cellular componentcytosolic large ribosomal subunit
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0003735Molecular functionstructural constituent of ribosome
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRPL13A
Protein nameRibosomal protein L13a
Large ribosomal subunit protein uL13 (23 kDa highly basic protein) (60S ribosomal protein L13a)
Large ribosomal subunit protein uL13 (60S ribosomal protein L13a)
SynonymshCG_1998057
RPL13a
DescriptionFUNCTION: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions . Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes . Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation . In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex . Involved in methylation of rRNA . .

AccessionsQ9BSQ6
A0A096LPE0
Q0VGL3
M0QZU1
M0QYS1
ENST00000678713.1
A0A7I2V376
P40429
ENST00000621674.4
ENST00000391857.9
ENST00000624069.3
ENST00000679106.1
ENST00000484279.5
A0A7I2V5L3
ENST00000467825.2
A0A7I2V2L9
Q8J015
ENST00000678510.1