I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 27 studies | 33% ± 12% | |
| smooth muscle cell | 9 studies | 23% ± 5% | |
| endothelial cell | 6 studies | 27% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 27 studies | 33% ± 12% | |
| smooth muscle cell | 9 studies | 23% ± 5% | |
| endothelial cell | 6 studies | 27% ± 7% |
Insufficient scRNA-seq data for expression of GJC1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 1369.50 | 454 / 459 | 88% | 5.67 | 988 / 1118 |
| prostate | 99% | 1893.80 | 242 / 245 | 79% | 4.38 | 399 / 502 |
| thymus | 100% | 1088.60 | 650 / 653 | 78% | 4.63 | 472 / 605 |
| uterus | 100% | 4715.59 | 170 / 170 | 72% | 9.40 | 330 / 459 |
| lung | 100% | 1863.79 | 577 / 578 | 69% | 4.69 | 802 / 1155 |
| bladder | 100% | 2725.00 | 21 / 21 | 67% | 5.50 | 337 / 504 |
| skin | 70% | 1093.09 | 1266 / 1809 | 97% | 16.30 | 457 / 472 |
| esophagus | 86% | 1690.16 | 1242 / 1445 | 79% | 6.09 | 144 / 183 |
| brain | 79% | 587.99 | 2083 / 2642 | 75% | 6.59 | 529 / 705 |
| intestine | 91% | 4271.74 | 876 / 966 | 43% | 2.05 | 226 / 527 |
| stomach | 72% | 1576.99 | 258 / 359 | 60% | 3.79 | 172 / 286 |
| ovary | 69% | 475.16 | 125 / 180 | 35% | 1.88 | 150 / 430 |
| adipose | 100% | 1654.64 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 1712.21 | 856 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 1166.31 | 1307 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 31% | 178.80 | 28 / 89 | 66% | 10.47 | 595 / 901 |
| pancreas | 7% | 26.30 | 22 / 328 | 74% | 3.87 | 131 / 178 |
| adrenal gland | 9% | 32.40 | 22 / 258 | 67% | 4.23 | 154 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 2.99 | 19 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 4.26 | 29 / 45 |
| muscle | 63% | 292.74 | 505 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 36% | 1.49 | 29 / 80 |
| liver | 1% | 3.75 | 2 / 226 | 27% | 1.29 | 110 / 406 |
| peripheral blood | 15% | 168.07 | 142 / 929 | 0% | 0 | 0 / 0 |
| spleen | 2% | 7.74 | 5 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0086053 | Biological process | AV node cell to bundle of His cell communication by electrical coupling |
| GO_0007601 | Biological process | visual perception |
| GO_0007043 | Biological process | cell-cell junction assembly |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0006936 | Biological process | muscle contraction |
| GO_0086014 | Biological process | atrial cardiac muscle cell action potential |
| GO_0086021 | Biological process | SA node cell to atrial cardiac muscle cell communication by electrical coupling |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0048468 | Biological process | cell development |
| GO_0048738 | Biological process | cardiac muscle tissue development |
| GO_0016264 | Biological process | gap junction assembly |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005922 | Cellular component | connexin complex |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0045202 | Cellular component | synapse |
| GO_0005921 | Cellular component | gap junction |
| GO_0014704 | Cellular component | intercalated disc |
| GO_0005216 | Molecular function | monoatomic ion channel activity |
| GO_0086077 | Molecular function | gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling |
| GO_0005243 | Molecular function | gap junction channel activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0086020 | Molecular function | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling |
| Gene name | GJC1 |
| Protein name | Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein) Gap junction protein Gap junction protein gamma 1 |
| Synonyms | GJA7 DKFZp686P0738 |
| Description | FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. . |
| Accessions | ENST00000330514.4 ENST00000590758.3 ENST00000587113.1 ENST00000586267.1 P36383 ENST00000587239.5 ENST00000586347.1 K7EQ14 K7ENT9 K7EM78 Q5H9P2 ENST00000591424.5 K7ERH3 ENST00000592524.6 |
