PAK5 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	59% ± 19%	Explore
GABAergic neuron	10 studies	50% ± 23%	Explore
retina horizontal cell	6 studies	65% ± 15%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 7%	Explore
interneuron	5 studies	63% ± 11%	Explore
neuron	4 studies	38% ± 15%	Explore
amacrine cell	4 studies	48% ± 24%	Explore
GABAergic amacrine cell	3 studies	34% ± 9%	Explore
glycinergic amacrine cell	3 studies	40% ± 16%	Explore
granule cell	3 studies	49% ± 12%	Explore

Name	Number of supported studies	Average coverage
brain	10 studies	42% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	1270.96	2480 / 2642	80%	6.74	566 / 705
adrenal gland	97%	411.29	251 / 258	72%	3.90	166 / 230
pancreas	59%	84.94	193 / 328	22%	0.56	40 / 178
breast	35%	73.40	161 / 459	9%	0.20	105 / 1118
prostate	34%	41.65	83 / 245	10%	0.15	52 / 502
blood vessel	38%	75.97	508 / 1335	0%	0	0 / 0
esophagus	8%	14.78	117 / 1445	16%	0.55	29 / 183
lung	0%	0.36	2 / 578	22%	1.12	257 / 1155
ovary	0%	0	0 / 180	12%	0.31	52 / 430
uterus	1%	0.62	1 / 170	10%	0.29	48 / 459
stomach	6%	11.34	23 / 359	5%	0.10	13 / 286
kidney	6%	7.06	5 / 89	5%	0.31	48 / 901
bladder	0%	0	0 / 21	7%	0.30	33 / 504
liver	0%	0	0 / 226	6%	1.03	25 / 406
tonsil	0%	0	0 / 0	4%	0.15	2 / 45
thymus	0%	0	0 / 653	3%	0.06	20 / 605
intestine	0%	0.73	4 / 966	3%	0.13	15 / 527
skin	1%	1.37	23 / 1809	1%	0.09	6 / 472
eye	0%	0	0 / 0	3%	0.08	2 / 80
heart	0%	0.24	2 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0008283	Biological process	cell population proliferation
GO_0001558	Biological process	regulation of cell growth
GO_0007612	Biological process	learning
GO_0007165	Biological process	signal transduction
GO_0007010	Biological process	cytoskeleton organization
GO_0035556	Biological process	intracellular signal transduction
GO_0007626	Biological process	locomotory behavior
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0007613	Biological process	memory
GO_0006915	Biological process	apoptotic process
GO_0006468	Biological process	protein phosphorylation
GO_0043408	Biological process	regulation of MAPK cascade
GO_0016477	Biological process	cell migration
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0031965	Cellular component	nuclear membrane
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	PAK5
Protein name	Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)
Synonyms	PAK7 KIAA1264
Description	FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. .
Accessions	ENST00000353224.10 ENST00000378423.5 ENST00000378429.3 Q9P286

PAK5 report