GPC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098696Biological processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0009966Biological processregulation of signal transduction
GO_0016477Biological processcell migration
GO_0005796Cellular componentGolgi lumen
GO_0009986Cellular componentcell surface
GO_0043202Cellular componentlysosomal lumen
GO_0098552Cellular componentside of membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0045202Cellular componentsynapse
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0015026Molecular functioncoreceptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPC6
Protein nameGlypican-6 [Cleaved into: Secreted glypican-6]
SynonymsUNQ369/PRO705
DescriptionFUNCTION: Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling. .

AccessionsENST00000377047.9
Q9Y625