CHRNA1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CHRNA1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHRNA1 at tissue level.

III. Associated gene sets

GO_0042391Biological processregulation of membrane potential
GO_0051899Biological processmembrane depolarization
GO_0003009Biological processskeletal muscle contraction
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0060079Biological processexcitatory postsynaptic potential
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0095500Biological processacetylcholine receptor signaling pathway
GO_0050905Biological processneuromuscular process
GO_0007274Biological processneuromuscular synaptic transmission
GO_0007528Biological processneuromuscular junction development
GO_0070050Biological processneuron cellular homeostasis
GO_0019228Biological processneuronal action potential
GO_0035094Biological processresponse to nicotine
GO_0006812Biological processmonoatomic cation transport
GO_0048630Biological processskeletal muscle tissue growth
GO_0050881Biological processmusculoskeletal movement
GO_0007271Biological processsynaptic transmission, cholinergic
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043005Cellular componentneuron projection
GO_0009986Cellular componentcell surface
GO_0045202Cellular componentsynapse
GO_0099634Cellular componentpostsynaptic specialization membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0005892Cellular componentacetylcholine-gated channel complex
GO_1904315Molecular functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0015464Molecular functionacetylcholine receptor activity
GO_0042166Molecular functionacetylcholine binding
GO_0022848Molecular functionacetylcholine-gated monoatomic cation-selective channel activity

IV. Literature review

[source]
Gene nameCHRNA1
Protein nameCholinergic receptor nicotinic alpha 1 subunit
Acetylcholine receptor subunit alpha
SynonymsCHNRA
hCG_1811440
ACHRA
DescriptionFUNCTION: [Isoform 1]: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .; FUNCTION: [Isoform 2]: Non functional acetylcholine receptor alpha subunit which is not integrated into functional acetylcholine-gated cation-selective channels. .

FUNCTION: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

FUNCTION: Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

AccessionsG5E9G9
P02708
B8ZZD3
E7ENE5
Q53SH4
ENST00000636168.2
ENST00000409323.1
ENST00000348749.9 [P02708-2]
F8WDS3
ENST00000435083.5
ENST00000672640.1
ENST00000409219.5
ENST00000409542.5
A0A1B0GV17
ENST00000261007.9 [P02708-1]