C22orf39 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0048167Biological processregulation of synaptic plasticity
GO_0043083Cellular componentsynaptic cleft
GO_0045202Cellular componentsynapse
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameC22orf39
Protein nameSynaptic plasticity regulator PANTS (Plasticity-associated neural transcript short)
Synonyms
DescriptionFUNCTION: Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses. .

AccessionsENST00000399562.9 [Q6P5X5-1]
ENST00000399568.5 [Q6P5X5-2]
ENST00000509549.5
E0CX16
Q6P5X5