CAPRIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_0062029Biological processpositive regulation of stress granule assembly
GO_0048699Biological processgeneration of neurons
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0106288Biological processregulation of deadenylation-dependent decapping of nuclear-transcribed mRNA
GO_0008298Biological processintracellular mRNA localization
GO_0007416Biological processsynapse assembly
GO_0017148Biological processnegative regulation of translation
GO_0016020Cellular componentmembrane
GO_0031252Cellular componentcell leading edge
GO_0030425Cellular componentdendrite
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0010494Cellular componentcytoplasmic stress granule
GO_0140677Molecular functionmolecular function activator activity
GO_0003729Molecular functionmRNA binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAPRIN1
Protein nameCell cycle associated protein 1 (GPI-anchored membrane protein 1, isoform CRA_d)
Cell cycle associated protein 1
Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)
SynonymsGPIAP1
hCG_27570
RNG105
M11S1
GPIP137
DescriptionFUNCTION: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types . Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors . Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs . In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation . Binds directly and selectively to MYC and CCND2 mRNAs . In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs . .

AccessionsENST00000530820.5 [Q14444-2]
ENST00000532820.5 [Q14444-1]
G3V153
ENST00000389645.7 [Q14444-2]
ENST00000534825.5
E9PLA9
ENST00000529307.1
Q14444
ENST00000341394.9 [Q14444-1]