I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 7 studies | 39% ± 26% | |
| chondrocyte | 4 studies | 56% ± 18% | |
| connective tissue cell | 3 studies | 36% ± 7% | |
| endothelial cell | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 7 studies | 39% ± 26% | |
| chondrocyte | 4 studies | 56% ± 18% | |
| connective tissue cell | 3 studies | 36% ± 7% | |
| endothelial cell | 3 studies | 20% ± 3% |
Insufficient scRNA-seq data for expression of HAPLN1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 76% | 165.61 | 2014 / 2642 | 92% | 17.08 | 652 / 705 |
| esophagus | 52% | 58.89 | 745 / 1445 | 56% | 2.47 | 102 / 183 |
| stomach | 58% | 95.98 | 209 / 359 | 47% | 1.45 | 134 / 286 |
| intestine | 61% | 225.50 | 592 / 966 | 42% | 1.13 | 221 / 527 |
| blood vessel | 82% | 670.21 | 1101 / 1335 | 0% | 0 | 0 / 0 |
| lung | 47% | 90.42 | 271 / 578 | 28% | 1.32 | 328 / 1155 |
| bladder | 24% | 88.43 | 5 / 21 | 45% | 1.79 | 228 / 504 |
| kidney | 10% | 9.28 | 9 / 89 | 58% | 6.12 | 520 / 901 |
| heart | 62% | 124.56 | 534 / 861 | 0% | 0 | 0 / 0 |
| breast | 19% | 18.58 | 89 / 459 | 39% | 3.53 | 440 / 1118 |
| uterus | 2% | 1.53 | 3 / 170 | 56% | 4.50 | 255 / 459 |
| ovary | 6% | 5.59 | 11 / 180 | 49% | 1.48 | 212 / 430 |
| prostate | 43% | 113.63 | 106 / 245 | 12% | 0.30 | 58 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 1.99 | 24 / 45 |
| skin | 29% | 81.17 | 530 / 1809 | 20% | 20.51 | 94 / 472 |
| thymus | 5% | 4.68 | 32 / 653 | 44% | 1.62 | 266 / 605 |
| adrenal gland | 0% | 3.26 | 1 / 258 | 37% | 1.97 | 85 / 230 |
| pancreas | 0% | 0 | 0 / 328 | 37% | 1.13 | 65 / 178 |
| liver | 0% | 0 | 0 / 226 | 3% | 0.45 | 14 / 406 |
| adipose | 1% | 1.20 | 13 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 1% | 1.05 | 2 / 241 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.13 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002052 | Biological process | positive regulation of neuroblast proliferation |
| GO_0001501 | Biological process | skeletal system development |
| GO_0010001 | Biological process | glial cell differentiation |
| GO_0007155 | Biological process | cell adhesion |
| GO_0007417 | Biological process | central nervous system development |
| GO_0005615 | Cellular component | extracellular space |
| GO_0045202 | Cellular component | synapse |
| GO_0005576 | Cellular component | extracellular region |
| GO_0072534 | Cellular component | perineuronal net |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0030021 | Molecular function | extracellular matrix structural constituent conferring compression resistance |
| GO_0005540 | Molecular function | hyaluronic acid binding |
| Gene name | HAPLN1 |
| Protein name | Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Proteoglycan link protein) Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) Hyaluronan and proteoglycan link protein 1 |
| Synonyms | CRTL1 |
| Description | FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. . FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. . FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. . |
| Accessions | ENST00000514416.5 P10915 ENST00000508307.5 D6RBS1 ENST00000510978.5 D6RFI7 D6RG04 D6RBX9 ENST00000515590.1 D6RC59 D6RAK7 ENST00000503117.1 ENST00000504713.5 ENST00000274341.9 |
