GABRB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	18 studies	58% ± 26%	Explore
glutamatergic neuron	12 studies	67% ± 25%	Explore
GABAergic neuron	11 studies	55% ± 28%	Explore
oligodendrocyte precursor cell	10 studies	40% ± 16%	Explore
neuron	5 studies	35% ± 15%	Explore
interneuron	5 studies	65% ± 30%	Explore
endothelial cell	4 studies	39% ± 18%	Explore
granule cell	4 studies	35% ± 27%	Explore
cardiac muscle cell	4 studies	27% ± 3%	Explore
Mueller cell	4 studies	41% ± 11%	Explore
GABAergic interneuron	3 studies	68% ± 14%	Explore
microglial cell	3 studies	35% ± 17%	Explore
ependymal cell	3 studies	31% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	43% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	170.78	2554 / 2642	84%	6.45	592 / 705
heart	56%	24.36	486 / 861	0%	0	0 / 0
blood vessel	51%	26.22	684 / 1335	0%	0	0 / 0
stomach	1%	0.23	4 / 359	15%	0.44	42 / 286
intestine	4%	0.85	36 / 966	7%	0.23	39 / 527
esophagus	1%	0.17	9 / 1445	8%	0.33	14 / 183
uterus	5%	2.20	9 / 170	3%	0.13	12 / 459
eye	0%	0	0 / 0	6%	0.18	5 / 80
skin	1%	0.11	10 / 1809	5%	0.15	25 / 472
thymus	1%	0.26	7 / 653	2%	0.03	12 / 605
kidney	0%	0	0 / 89	3%	0.09	27 / 901
adrenal gland	1%	0.17	2 / 258	2%	0.04	5 / 230
lung	0%	0	0 / 578	3%	0.12	33 / 1155
bladder	0%	0	0 / 21	3%	0.14	14 / 504
breast	0%	0	0 / 459	3%	0.10	28 / 1118
ovary	0%	0	0 / 180	2%	0.04	9 / 430
adipose	2%	0.42	20 / 1204	0%	0	0 / 0
liver	0%	0	0 / 226	1%	0.04	6 / 406
pancreas	0%	0	0 / 328	1%	0.02	2 / 178
spleen	0%	0.10	1 / 241	0%	0	0 / 0
peripheral blood	0%	0.04	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071420	Biological process	cellular response to histamine
GO_0042391	Biological process	regulation of membrane potential
GO_0007165	Biological process	signal transduction
GO_0006811	Biological process	monoatomic ion transport
GO_0042698	Biological process	ovulation cycle
GO_0099505	Biological process	regulation of presynaptic membrane potential
GO_1902476	Biological process	chloride transmembrane transport
GO_0007268	Biological process	chemical synaptic transmission
GO_0021954	Biological process	central nervous system neuron development
GO_0060078	Biological process	regulation of postsynaptic membrane potential
GO_0007214	Biological process	gamma-aminobutyric acid signaling pathway
GO_0009636	Biological process	response to toxic substance
GO_0032570	Biological process	response to progesterone
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0048787	Cellular component	presynaptic active zone membrane
GO_1902495	Cellular component	transmembrane transporter complex
GO_0005635	Cellular component	nuclear envelope
GO_0043005	Cellular component	neuron projection
GO_0030425	Cellular component	dendrite
GO_0098982	Cellular component	GABA-ergic synapse
GO_0034707	Cellular component	chloride channel complex
GO_0045202	Cellular component	synapse
GO_0099634	Cellular component	postsynaptic specialization membrane
GO_1902711	Cellular component	GABA-A receptor complex
GO_1904315	Molecular function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GO_0004890	Molecular function	GABA-A receptor activity
GO_0050811	Molecular function	GABA receptor binding
GO_0150047	Molecular function	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential
GO_0015276	Molecular function	ligand-gated monoatomic ion channel activity
GO_0030594	Molecular function	neurotransmitter receptor activity
GO_0022851	Molecular function	GABA-gated chloride ion channel activity
GO_0099507	Molecular function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GO_0005254	Molecular function	chloride channel activity

IV. Literature review

[source]

Gene name	GABRB1
Protein name	Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) Gamma-aminobutyric acid type A receptor subunit beta1 Gamma-aminobutyric acid A receptor beta 1 isoform A
Synonyms
Description	FUNCTION: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as a receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as a ligand-gated chloride channel. .
Accessions	ENST00000295454.8 [P18505-1] ENST00000513567.5 P18505 X5DNL6 D6REM0 ENST00000510909.1 [P18505-2]

GABRB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review