Insufficient scRNA-seq data for expression of SLC12A4 at single-cell level.
Insufficient scRNA-seq data for expression of SLC12A4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 9414.80 | 653 / 653 | 100% | 34.27 | 603 / 605 |
| skin | 100% | 5473.59 | 1809 / 1809 | 100% | 28.76 | 470 / 472 |
| kidney | 100% | 3930.09 | 89 / 89 | 99% | 33.80 | 892 / 901 |
| uterus | 100% | 9202.75 | 170 / 170 | 98% | 22.27 | 451 / 459 |
| lung | 100% | 9027.81 | 578 / 578 | 97% | 19.03 | 1124 / 1155 |
| prostate | 100% | 7899.31 | 244 / 245 | 97% | 19.44 | 486 / 502 |
| breast | 100% | 7669.84 | 459 / 459 | 96% | 16.80 | 1076 / 1118 |
| bladder | 100% | 6719.67 | 21 / 21 | 96% | 19.27 | 485 / 504 |
| esophagus | 98% | 6508.07 | 1413 / 1445 | 98% | 18.97 | 180 / 183 |
| adrenal gland | 100% | 6720.49 | 258 / 258 | 95% | 19.87 | 219 / 230 |
| pancreas | 96% | 2666.56 | 314 / 328 | 98% | 24.73 | 174 / 178 |
| intestine | 99% | 5785.79 | 955 / 966 | 90% | 12.53 | 476 / 527 |
| stomach | 98% | 3870.62 | 351 / 359 | 91% | 13.16 | 260 / 286 |
| ovary | 100% | 5808.91 | 180 / 180 | 88% | 11.40 | 380 / 430 |
| liver | 94% | 2143.50 | 213 / 226 | 93% | 13.44 | 376 / 406 |
| brain | 78% | 1495.97 | 2050 / 2642 | 100% | 49.10 | 705 / 705 |
| adipose | 100% | 7697.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 9865.85 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 52.21 | 80 / 80 |
| spleen | 100% | 3805.44 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.38 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 10.19 | 1 / 1 |
| heart | 100% | 6423.06 | 859 / 861 | 0% | 0 | 0 / 0 |
| muscle | 97% | 2972.57 | 782 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 12.94 | 28 / 29 |
| peripheral blood | 37% | 818.22 | 344 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0140157 | Biological process | ammonium import across plasma membrane |
| GO_0055064 | Biological process | chloride ion homeostasis |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0006884 | Biological process | cell volume homeostasis |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0055075 | Biological process | potassium ion homeostasis |
| GO_1990573 | Biological process | potassium ion import across plasma membrane |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0045202 | Cellular component | synapse |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0015379 | Molecular function | potassium:chloride symporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0008519 | Molecular function | ammonium channel activity |
| Gene name | SLC12A4 |
| Protein name | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) Solute carrier family 12 member 4 Solute carrier family 12 (Potassium/chloride transporters), member 4, isoform CRA_e (cDNA FLJ40489 fis, clone TESTI2044194, highly similar to Solute carrier family 12 member 4) |
| Synonyms | hCG_2039906 KCC1 |
| Description | FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells . May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). .; FUNCTION: [Isoform 4]: No transporter activity. . |
| Accessions | J3QRE2 ENST00000705485.1 ENST00000570616.1 J3QKM4 I3L1N8 Q9UP95 ENST00000575857.3 I3L4N6 B3KUS0 A0A994J5J8 ENST00000572037.5 J3QSF2 ENST00000576616.5 [Q9UP95-2] ENST00000541864.7 [Q9UP95-5] ENST00000316341.8 [Q9UP95-1] ENST00000576377.2 ENST00000571299.5 ENST00000537830.6 [Q9UP95-6] |