CACNA1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0098703Biological processcalcium ion import across plasma membrane
GO_1904645Biological processresponse to amyloid-beta
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0007268Biological processchemical synaptic transmission
GO_1904646Biological processcellular response to amyloid-beta
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0043025Cellular componentneuronal cell body
GO_0005891Cellular componentvoltage-gated calcium channel complex
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0005634Cellular componentnucleus
GO_0001540Molecular functionamyloid-beta binding
GO_0005245Molecular functionvoltage-gated calcium channel activity
GO_0046872Molecular functionmetal ion binding
GO_0008331Molecular functionhigh voltage-gated calcium channel activity
GO_0005515Molecular functionprotein binding
GO_0019905Molecular functionsyntaxin binding

IV. Literature review

[source]
Gene nameCACNA1A
Protein nameCalcium voltage-gated channel subunit alpha1 A
Calcium channel alpha 1A subunit
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1)
Fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit
Voltage-dependent P/Q-type calcium channel subunit alpha
Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1)
P/Q type calcium channel alpha1A subunit
SynonymsCACN3
CACNL1A4
CACH4
DescriptionFUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. .

AccessionsENST00000636389.1
A0A1B0GUE5
A0A1B0GUS3
ENST00000636012.1
ENST00000638029.1
A0A1B0GUP3
A0A1B0GUM7
K7EIF8
A0A384DVW2
ENST00000637276.1 [O00555-5]
A0A1B0GTN7
ENST00000360228.11 [O00555-8]
ENST00000574974.3
ENST00000573710.7
K7EQ95
ENST00000573891.6
B5TYJ1
O00555
Q9UN69
ENST00000637769.1
ENST00000635727.1
ENST00000637736.1
ENST00000585802.6
A0A1B0GVX1
I3L391
Q9UHM9
B3SZS3
ENST00000637777.1
ENST00000592864.3
ENST00000636058.1
I3L2V5
ENST00000636549.1
A0A1B0GVD8
A0A590UJK2
ENST00000638009.2 [O00555-3]
ENST00000636768.1
A0A1B0GTW2
ENST00000637927.1
A0A1C7CYY9
ENST00000637297.1
A0A1B0GU74
A0A1B0GTG6
A0A1B0GTI4
A0A1B0GU81
ENST00000587525.5
ENST00000636473.1
ENST00000637819.1
ENST00000664864.1
A0A087WW63
ENST00000637432.1 [O00555-2]
O95387
Q9NS89
K7EKF7
ENST00000635895.1