Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte precursor cell | 14 studies | 63% ± 19% | |
glutamatergic neuron | 13 studies | 68% ± 23% | |
microglial cell | 12 studies | 35% ± 16% | |
GABAergic neuron | 10 studies | 65% ± 25% | |
amacrine cell | 7 studies | 60% ± 15% | |
retinal ganglion cell | 7 studies | 57% ± 24% | |
astrocyte | 7 studies | 35% ± 18% | |
interneuron | 6 studies | 75% ± 23% | |
retina horizontal cell | 6 studies | 65% ± 20% | |
neuron | 5 studies | 43% ± 14% | |
smooth muscle cell | 5 studies | 22% ± 4% | |
enteroendocrine cell | 5 studies | 52% ± 28% | |
endothelial cell | 4 studies | 59% ± 17% | |
granule cell | 4 studies | 71% ± 14% | |
OFF-bipolar cell | 4 studies | 50% ± 12% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 51% ± 9% | |
GABAergic interneuron | 3 studies | 70% ± 7% | |
GABAergic amacrine cell | 3 studies | 59% ± 14% | |
glycinergic amacrine cell | 3 studies | 42% ± 10% | |
oligodendrocyte | 3 studies | 38% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 16936.62 | 2638 / 2642 | 86% | 4.11 | 608 / 705 |
ovary | 13% | 135.06 | 23 / 180 | 49% | 1.20 | 209 / 430 |
pancreas | 43% | 337.91 | 142 / 328 | 18% | 1.16 | 32 / 178 |
adrenal gland | 15% | 208.59 | 39 / 258 | 24% | 0.79 | 56 / 230 |
lymph node | 0% | 0 | 0 / 0 | 31% | 0.65 | 9 / 29 |
blood vessel | 26% | 201.29 | 343 / 1335 | 0% | 0 | 0 / 0 |
adipose | 25% | 136.09 | 303 / 1204 | 0% | 0 | 0 / 0 |
stomach | 20% | 127.66 | 72 / 359 | 5% | 0.46 | 14 / 286 |
intestine | 20% | 115.57 | 192 / 966 | 3% | 0.14 | 18 / 527 |
breast | 17% | 91.59 | 77 / 459 | 2% | 0.03 | 17 / 1118 |
uterus | 11% | 90.55 | 19 / 170 | 6% | 0.12 | 28 / 459 |
skin | 13% | 102.88 | 244 / 1809 | 3% | 0.10 | 16 / 472 |
thymus | 16% | 81.49 | 102 / 653 | 0% | 0 | 0 / 605 |
esophagus | 2% | 12.93 | 26 / 1445 | 7% | 0.42 | 13 / 183 |
peripheral blood | 6% | 39.58 | 60 / 929 | 0% | 0 | 0 / 0 |
lung | 0% | 0 | 0 / 578 | 3% | 0.10 | 34 / 1155 |
eye | 0% | 0 | 0 / 0 | 3% | 0.03 | 2 / 80 |
prostate | 2% | 10.54 | 6 / 245 | 0% | 0 | 0 / 502 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.02 | 1 / 45 |
bladder | 0% | 0 | 0 / 21 | 2% | 0.10 | 10 / 504 |
spleen | 2% | 7.30 | 4 / 241 | 0% | 0 | 0 / 0 |
kidney | 0% | 0 | 0 / 89 | 1% | 0.03 | 8 / 901 |
heart | 1% | 3.66 | 7 / 861 | 0% | 0 | 0 / 0 |
muscle | 1% | 3.71 | 5 / 803 | 0% | 0 | 0 / 0 |
liver | 0% | 1.73 | 1 / 226 | 0% | 0 | 0 / 406 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0050804 | Biological process | modulation of chemical synaptic transmission |
GO_0098703 | Biological process | calcium ion import across plasma membrane |
GO_1904645 | Biological process | response to amyloid-beta |
GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
GO_0007268 | Biological process | chemical synaptic transmission |
GO_1904646 | Biological process | cellular response to amyloid-beta |
GO_0070588 | Biological process | calcium ion transmembrane transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0005891 | Cellular component | voltage-gated calcium channel complex |
GO_0045202 | Cellular component | synapse |
GO_0005737 | Cellular component | cytoplasm |
GO_0042995 | Cellular component | cell projection |
GO_0005634 | Cellular component | nucleus |
GO_0001540 | Molecular function | amyloid-beta binding |
GO_0005245 | Molecular function | voltage-gated calcium channel activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0008331 | Molecular function | high voltage-gated calcium channel activity |
GO_0005515 | Molecular function | protein binding |
GO_0019905 | Molecular function | syntaxin binding |
Gene name | CACNA1A |
Protein name | Calcium voltage-gated channel subunit alpha1 A Calcium channel alpha 1A subunit Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage-gated calcium channel subunit alpha Cav2.1) Fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit Voltage-dependent P/Q-type calcium channel subunit alpha Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Brain calcium channel I) (BI) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Voltage-gated calcium channel subunit alpha Cav2.1) P/Q type calcium channel alpha1A subunit |
Synonyms | CACN3 CACNL1A4 CACH4 |
Description | FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. . |
Accessions | ENST00000636389.1 A0A1B0GUE5 A0A1B0GUS3 ENST00000636012.1 ENST00000638029.1 A0A1B0GUP3 A0A1B0GUM7 K7EIF8 A0A384DVW2 ENST00000637276.1 [O00555-5] A0A1B0GTN7 ENST00000360228.11 [O00555-8] ENST00000574974.3 ENST00000573710.7 K7EQ95 ENST00000573891.6 B5TYJ1 O00555 Q9UN69 ENST00000637769.1 ENST00000635727.1 ENST00000637736.1 ENST00000585802.6 A0A1B0GVX1 I3L391 Q9UHM9 B3SZS3 ENST00000637777.1 ENST00000592864.3 ENST00000636058.1 I3L2V5 ENST00000636549.1 A0A1B0GVD8 A0A590UJK2 ENST00000638009.2 [O00555-3] ENST00000636768.1 A0A1B0GTW2 ENST00000637927.1 A0A1C7CYY9 ENST00000637297.1 A0A1B0GU74 A0A1B0GTG6 A0A1B0GTI4 A0A1B0GU81 ENST00000587525.5 ENST00000636473.1 ENST00000637819.1 ENST00000664864.1 A0A087WW63 ENST00000637432.1 [O00555-2] O95387 Q9NS89 K7EKF7 ENST00000635895.1 |