SNAPIN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0016188Biological processsynaptic vesicle maturation
GO_0051036Biological processregulation of endosome size
GO_0062196Biological processregulation of lysosome size
GO_0008090Biological processretrograde axonal transport
GO_0007042Biological processlysosomal lumen acidification
GO_0031175Biological processneuron projection development
GO_0007269Biological processneurotransmitter secretion
GO_0008089Biological processanterograde axonal transport
GO_0072384Biological processorganelle transport along microtubule
GO_0006886Biological processintracellular protein transport
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0032438Biological processmelanosome organization
GO_0043393Biological processregulation of protein binding
GO_0048490Biological processanterograde synaptic vesicle transport
GO_0070050Biological processneuron cellular homeostasis
GO_0010977Biological processnegative regulation of neuron projection development
GO_1902824Biological processpositive regulation of late endosome to lysosome transport
GO_0008333Biological processendosome to lysosome transport
GO_0032418Biological processlysosome localization
GO_1902774Biological processlate endosome to lysosome transport
GO_0072553Biological processterminal button organization
GO_0031629Biological processsynaptic vesicle fusion to presynaptic active zone membrane
GO_0097352Biological processautophagosome maturation
GO_0031503Biological processprotein-containing complex localization
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0051604Biological processprotein maturation
GO_0048489Biological processsynaptic vesicle transport
GO_0099078Cellular componentBORC complex
GO_0001669Cellular componentacrosomal vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_1990742Cellular componentmicrovesicle
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0002177Cellular componentmanchette
GO_0098574Cellular componentcytoplasmic side of lysosomal membrane
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0045202Cellular componentsynapse
GO_0031083Cellular componentBLOC-1 complex
GO_0030141Cellular componentsecretory granule
GO_1904115Cellular componentaxon cytoplasm
GO_0000149Molecular functionSNARE binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNAPIN
Protein nameSNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein)
SynonymsSNAPAP
BLOC1S7
SNAP25BP
DescriptionFUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells . As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor . .

AccessionsENST00000368685.6
O95295