CHRNB2 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHRNB2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	2053.12	2491 / 2642	94%	13.64	666 / 705
adrenal gland	13%	47.68	34 / 258	67%	17.79	155 / 230
eye	0%	0	0 / 0	46%	1.82	37 / 80
skin	1%	1.64	17 / 1809	35%	2.02	166 / 472
pancreas	7%	13.51	24 / 328	28%	1.49	49 / 178
breast	9%	18.93	41 / 459	22%	1.89	251 / 1118
intestine	9%	16.33	89 / 966	6%	0.62	31 / 527
lung	0%	0	0 / 578	11%	0.71	131 / 1155
esophagus	0%	0.65	6 / 1445	10%	0.49	19 / 183
stomach	2%	3.71	8 / 359	8%	0.67	22 / 286
kidney	1%	2.22	1 / 89	7%	0.20	59 / 901
uterus	0%	0	0 / 170	5%	0.10	25 / 459
bladder	0%	0	0 / 21	5%	0.31	23 / 504
tonsil	0%	0	0 / 0	4%	0.30	2 / 45
ovary	1%	0.94	1 / 180	3%	0.29	13 / 430
liver	0%	0	0 / 226	3%	0.13	14 / 406
prostate	0%	0	0 / 245	1%	0.06	5 / 502
thymus	0%	0	0 / 653	1%	0.06	6 / 605
peripheral blood	1%	0.97	5 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0019233	Biological process	sensory perception of pain
GO_0014059	Biological process	regulation of dopamine secretion
GO_0006939	Biological process	smooth muscle contraction
GO_0007601	Biological process	visual perception
GO_0007605	Biological process	sensory perception of sound
GO_0033603	Biological process	positive regulation of dopamine secretion
GO_0051899	Biological process	membrane depolarization
GO_0048814	Biological process	regulation of dendrite morphogenesis
GO_0007612	Biological process	learning
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0032225	Biological process	regulation of synaptic transmission, dopaminergic
GO_0007165	Biological process	signal transduction
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0006811	Biological process	monoatomic ion transport
GO_0095500	Biological process	acetylcholine receptor signaling pathway
GO_0042053	Biological process	regulation of dopamine metabolic process
GO_0008306	Biological process	associative learning
GO_0035095	Biological process	behavioral response to nicotine
GO_0060084	Biological process	synaptic transmission involved in micturition
GO_0045471	Biological process	response to ethanol
GO_0008542	Biological process	visual learning
GO_0021631	Biological process	optic nerve morphogenesis
GO_0042220	Biological process	response to cocaine
GO_0021952	Biological process	central nervous system projection neuron axonogenesis
GO_1905144	Biological process	response to acetylcholine
GO_0042320	Biological process	regulation of circadian sleep/wake cycle, REM sleep
GO_0007268	Biological process	chemical synaptic transmission
GO_0051963	Biological process	regulation of synapse assembly
GO_0001666	Biological process	response to hypoxia
GO_0042113	Biological process	B cell activation
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_0035094	Biological process	response to nicotine
GO_0007626	Biological process	locomotory behavior
GO_0045759	Biological process	negative regulation of action potential
GO_0007613	Biological process	memory
GO_0050890	Biological process	cognition
GO_0021771	Biological process	lateral geniculate nucleus development
GO_0035176	Biological process	social behavior
GO_0007271	Biological process	synaptic transmission, cholinergic
GO_0050877	Biological process	nervous system process
GO_0006816	Biological process	calcium ion transport
GO_0021562	Biological process	vestibulocochlear nerve development
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043005	Cellular component	neuron projection
GO_0042734	Cellular component	presynaptic membrane
GO_0098981	Cellular component	cholinergic synapse
GO_0044853	Cellular component	plasma membrane raft
GO_0045202	Cellular component	synapse
GO_0099634	Cellular component	postsynaptic specialization membrane
GO_0005892	Cellular component	acetylcholine-gated channel complex
GO_1901363	Molecular function	heterocyclic compound binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0015464	Molecular function	acetylcholine receptor activity
GO_0015276	Molecular function	ligand-gated monoatomic ion channel activity
GO_0042166	Molecular function	acetylcholine binding
GO_0022848	Molecular function	acetylcholine-gated monoatomic cation-selective channel activity
GO_0050997	Molecular function	quaternary ammonium group binding
GO_0005515	Molecular function	protein binding

Gene name	CHRNB2
Protein name	Neuronal acetylcholine receptor subunit beta-2 Cholinergic receptor, nicotinic, beta 2 (Neuronal) (cDNA, FLJ94017, Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 2(neuronal) (CHRNB2), mRNA) Cholinergic receptor nicotinic beta 2 subunit
Synonyms	hCG_18732
Description	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. .
Accessions	A0A1B0GVD7 P17787 ENST00000636034.1 ENST00000637900.1 ENST00000368476.4 Q5SXY3 A0A1B0GTH5

CHRNB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review