RTN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990809Biological processendoplasmic reticulum tubular network membrane organization
GO_0071786Biological processendoplasmic reticulum tubular network organization
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0071787Biological processendoplasmic reticulum tubular network formation
GO_1905552Biological processpositive regulation of protein localization to endoplasmic reticulum
GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0051292Biological processnuclear pore complex assembly
GO_2000172Biological processregulation of branching morphogenesis of a nerve
GO_0060317Biological processcardiac epithelial to mesenchymal transition
GO_0007413Biological processaxonal fasciculation
GO_0030182Biological processneuron differentiation
GO_0090156Biological processintracellular sphingolipid homeostasis
GO_0042981Biological processregulation of apoptotic process
GO_0034165Biological processpositive regulation of toll-like receptor 9 signaling pathway
GO_0061462Biological processprotein localization to lysosome
GO_0050821Biological processprotein stabilization
GO_1905580Biological processpositive regulation of ERBB3 signaling pathway
GO_0007420Biological processbrain development
GO_0006915Biological processapoptotic process
GO_0030517Biological processnegative regulation of axon extension
GO_0033601Biological processpositive regulation of mammary gland epithelial cell proliferation
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0001825Biological processblastocyst formation
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0021801Biological processcerebral cortex radial glia-guided migration
GO_0030308Biological processnegative regulation of cell growth
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0005635Cellular componentnuclear envelope
GO_0043005Cellular componentneuron projection
GO_0005783Cellular componentendoplasmic reticulum
GO_0045202Cellular componentsynapse
GO_0070161Cellular componentanchoring junction
GO_0014069Cellular componentpostsynaptic density
GO_0098826Cellular componentendoplasmic reticulum tubular network membrane
GO_0045296Molecular functioncadherin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRTN4
Protein nameReticulon 4
Reticulon
Uncharacterized protein RTN4
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
SynonymsMy043
KIAA0886
NOGO
SP1507
DescriptionFUNCTION: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules . They regulate membrane morphogenesis in the ER by promoting tubular ER production . They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins . However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). .; FUNCTION: [Isoform A]: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS . Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity). .; FUNCTION: [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration . With isoform C, inhibits BACE1 activity and amyloid precursor protein processing . .; FUNCTION: [Isoform C]: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing . .

AccessionsENST00000394611.6 [Q9NQC3-6]
Q53RF4
ENST00000357732.8 [Q9NQC3-5]
ENST00000394609.6 [Q9NQC3-3]
Q53R94
Q9NQC3
ENST00000427710.5
ENST00000337526.11 [Q9NQC3-1]
ENST00000405240.5 [Q9NQC3-6]
A0A0U1RQR6
C9J685
ENST00000357376.7 [Q9NQC3-6]
ENST00000317610.11 [Q9NQC3-2]
Q6IPN0
H7C106
ENST00000486085.5
ENST00000438462.1
ENST00000404909.5 [Q9NQC3-6]
Q53SY1