Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 34 studies | 50% ± 22% | |
fibroblast | 33 studies | 43% ± 21% | |
mast cell | 26 studies | 57% ± 26% | |
smooth muscle cell | 24 studies | 35% ± 20% | |
endothelial cell of lymphatic vessel | 23 studies | 60% ± 19% | |
astrocyte | 23 studies | 82% ± 16% | |
basal cell | 20 studies | 50% ± 19% | |
ciliated cell | 19 studies | 63% ± 19% | |
epithelial cell | 18 studies | 51% ± 22% | |
oligodendrocyte | 14 studies | 33% ± 16% | |
oligodendrocyte precursor cell | 13 studies | 36% ± 16% | |
classical monocyte | 13 studies | 28% ± 10% | |
endothelial cell of vascular tree | 13 studies | 49% ± 19% | |
vein endothelial cell | 13 studies | 60% ± 24% | |
connective tissue cell | 12 studies | 41% ± 21% | |
platelet | 11 studies | 69% ± 20% | |
secretory cell | 11 studies | 53% ± 27% | |
club cell | 10 studies | 49% ± 27% | |
glutamatergic neuron | 10 studies | 52% ± 14% | |
endothelial cell of artery | 10 studies | 48% ± 13% | |
GABAergic neuron | 9 studies | 49% ± 16% | |
microglial cell | 9 studies | 43% ± 25% | |
pericyte | 8 studies | 39% ± 21% | |
myofibroblast cell | 8 studies | 60% ± 30% | |
T cell | 7 studies | 39% ± 27% | |
interneuron | 7 studies | 45% ± 27% | |
abnormal cell | 7 studies | 55% ± 20% | |
neuron | 7 studies | 45% ± 20% | |
mesothelial cell | 7 studies | 45% ± 25% | |
respiratory goblet cell | 6 studies | 49% ± 19% | |
hepatocyte | 6 studies | 61% ± 29% | |
glial cell | 6 studies | 57% ± 31% | |
mucus secreting cell | 6 studies | 37% ± 26% | |
Mueller cell | 6 studies | 78% ± 22% | |
type II pneumocyte | 5 studies | 32% ± 20% | |
megakaryocyte | 5 studies | 73% ± 14% | |
epithelial cell of proximal tubule | 5 studies | 45% ± 22% | |
enteroendocrine cell | 5 studies | 26% ± 9% | |
progenitor cell | 5 studies | 36% ± 19% | |
retinal ganglion cell | 5 studies | 74% ± 28% | |
hematopoietic stem cell | 5 studies | 39% ± 24% | |
adventitial cell | 5 studies | 70% ± 25% | |
monocyte | 4 studies | 34% ± 15% | |
deuterosomal cell | 4 studies | 30% ± 7% | |
duct epithelial cell | 4 studies | 91% ± 2% | |
pancreatic A cell | 4 studies | 97% ± 3% | |
cholangiocyte | 4 studies | 55% ± 28% | |
endothelial cell of sinusoid | 4 studies | 28% ± 10% | |
macrophage | 4 studies | 49% ± 26% | |
kidney distal convoluted tubule epithelial cell | 4 studies | 60% ± 13% | |
kidney loop of Henle epithelial cell | 4 studies | 51% ± 12% | |
amacrine cell | 4 studies | 59% ± 11% | |
retinal pigment epithelial cell | 4 studies | 82% ± 12% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 68% ± 5% | |
mature NK T cell | 4 studies | 33% ± 11% | |
melanocyte | 4 studies | 37% ± 17% | |
type I pneumocyte | 3 studies | 29% ± 3% | |
pancreatic D cell | 3 studies | 95% ± 3% | |
type B pancreatic cell | 3 studies | 66% ± 11% | |
kidney connecting tubule epithelial cell | 3 studies | 85% ± 6% | |
renal alpha-intercalated cell | 3 studies | 51% ± 9% | |
enterocyte | 3 studies | 31% ± 6% | |
OFF-bipolar cell | 3 studies | 45% ± 30% | |
ON-bipolar cell | 3 studies | 43% ± 28% | |
GABAergic amacrine cell | 3 studies | 50% ± 9% | |
glycinergic amacrine cell | 3 studies | 44% ± 6% | |
retinal rod cell | 3 studies | 24% ± 6% | |
renal principal cell | 3 studies | 86% ± 10% | |
myeloid cell | 3 studies | 20% ± 4% | |
serous secreting cell | 3 studies | 38% ± 5% | |
acinar cell | 3 studies | 54% ± 6% | |
goblet cell | 3 studies | 28% ± 8% | |
granulocyte | 3 studies | 72% ± 15% | |
pancreatic ductal cell | 3 studies | 79% ± 10% | |
neural progenitor cell | 3 studies | 44% ± 23% | |
ependymal cell | 3 studies | 74% ± 18% | |
chondrocyte | 3 studies | 32% ± 13% | |
Schwann cell | 3 studies | 46% ± 34% | |
transit amplifying cell | 3 studies | 43% ± 28% | |
progenitor cell of mammary luminal epithelium | 3 studies | 57% ± 21% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 18 studies | 42% ± 19% | |
lung | 15 studies | 30% ± 11% | |
eye | 9 studies | 40% ± 16% | |
pancreas | 5 studies | 64% ± 22% | |
intestine | 5 studies | 20% ± 5% | |
kidney | 5 studies | 31% ± 10% | |
uterus | 5 studies | 45% ± 17% | |
peripheral blood | 4 studies | 18% ± 2% | |
breast | 4 studies | 38% ± 15% | |
ovary | 3 studies | 27% ± 7% | |
liver | 3 studies | 50% ± 4% | |
prostate | 3 studies | 42% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 183046.19 | 2637 / 2642 | 100% | 4583.85 | 702 / 705 |
liver | 100% | 133543.11 | 226 / 226 | 96% | 1676.02 | 390 / 406 |
adrenal gland | 99% | 148505.07 | 256 / 258 | 85% | 1169.74 | 196 / 230 |
thymus | 99% | 108826.74 | 649 / 653 | 85% | 3534.87 | 512 / 605 |
kidney | 72% | 44525.93 | 64 / 89 | 83% | 1319.36 | 744 / 901 |
ovary | 68% | 23888.62 | 122 / 180 | 80% | 1258.04 | 344 / 430 |
pancreas | 92% | 40345.94 | 302 / 328 | 52% | 388.66 | 92 / 178 |
breast | 92% | 41541.17 | 423 / 459 | 47% | 387.96 | 529 / 1118 |
uterus | 96% | 48273.95 | 163 / 170 | 20% | 175.29 | 93 / 459 |
bladder | 100% | 70909.38 | 21 / 21 | 15% | 100.95 | 77 / 504 |
blood vessel | 100% | 153181.45 | 1333 / 1335 | 0% | 0 | 0 / 0 |
lung | 82% | 31405.88 | 473 / 578 | 14% | 89.43 | 162 / 1155 |
prostate | 75% | 39881.23 | 184 / 245 | 17% | 77.65 | 83 / 502 |
adipose | 91% | 41132.31 | 1093 / 1204 | 0% | 0 | 0 / 0 |
esophagus | 71% | 36587.39 | 1019 / 1445 | 10% | 77.69 | 18 / 183 |
intestine | 69% | 36268.97 | 669 / 966 | 5% | 31.81 | 27 / 527 |
stomach | 64% | 33559.09 | 230 / 359 | 9% | 48.95 | 26 / 286 |
lymph node | 0% | 0 | 0 / 0 | 38% | 325.98 | 11 / 29 |
heart | 23% | 6713.83 | 199 / 861 | 0% | 0 | 0 / 0 |
skin | 8% | 2128.87 | 147 / 1809 | 4% | 32.87 | 21 / 472 |
eye | 0% | 0 | 0 / 0 | 13% | 107.83 | 10 / 80 |
tonsil | 0% | 0 | 0 / 0 | 11% | 50.18 | 5 / 45 |
peripheral blood | 7% | 2018.29 | 69 / 929 | 0% | 0 | 0 / 0 |
spleen | 3% | 820.26 | 8 / 241 | 0% | 0 | 0 / 0 |
muscle | 1% | 335.61 | 9 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1905908 | Biological process | positive regulation of amyloid fibril formation |
GO_0031333 | Biological process | negative regulation of protein-containing complex assembly |
GO_0032286 | Biological process | central nervous system myelin maintenance |
GO_0006956 | Biological process | complement activation |
GO_0031334 | Biological process | positive regulation of protein-containing complex assembly |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_1902847 | Biological process | regulation of neuronal signal transduction |
GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
GO_0050821 | Biological process | protein stabilization |
GO_0000902 | Biological process | cell morphogenesis |
GO_0061518 | Biological process | microglial cell proliferation |
GO_0045087 | Biological process | innate immune response |
GO_1900221 | Biological process | regulation of amyloid-beta clearance |
GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0051131 | Biological process | chaperone-mediated protein complex assembly |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0045429 | Biological process | positive regulation of nitric oxide biosynthetic process |
GO_1902998 | Biological process | positive regulation of neurofibrillary tangle assembly |
GO_0006629 | Biological process | lipid metabolic process |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0017038 | Biological process | protein import |
GO_0001774 | Biological process | microglial cell activation |
GO_0061077 | Biological process | chaperone-mediated protein folding |
GO_1902430 | Biological process | negative regulation of amyloid-beta formation |
GO_0090201 | Biological process | negative regulation of release of cytochrome c from mitochondria |
GO_1903573 | Biological process | negative regulation of response to endoplasmic reticulum stress |
GO_0006958 | Biological process | complement activation, classical pathway |
GO_1902004 | Biological process | positive regulation of amyloid-beta formation |
GO_1902230 | Biological process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
GO_1905907 | Biological process | negative regulation of amyloid fibril formation |
GO_0001836 | Biological process | release of cytochrome c from mitochondria |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0009615 | Biological process | response to virus |
GO_0043691 | Biological process | reverse cholesterol transport |
GO_0048260 | Biological process | positive regulation of receptor-mediated endocytosis |
GO_0061740 | Biological process | protein targeting to lysosome involved in chaperone-mediated autophagy |
GO_0051788 | Biological process | response to misfolded protein |
GO_0002434 | Biological process | immune complex clearance |
GO_0005856 | Cellular component | cytoskeleton |
GO_0009986 | Cellular component | cell surface |
GO_0071944 | Cellular component | cell periphery |
GO_0005634 | Cellular component | nucleus |
GO_0005576 | Cellular component | extracellular region |
GO_0097418 | Cellular component | neurofibrillary tangle |
GO_0070062 | Cellular component | extracellular exosome |
GO_0031093 | Cellular component | platelet alpha granule lumen |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005615 | Cellular component | extracellular space |
GO_0034366 | Cellular component | spherical high-density lipoprotein particle |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0042583 | Cellular component | chromaffin granule |
GO_0072562 | Cellular component | blood microparticle |
GO_0005737 | Cellular component | cytoplasm |
GO_0099020 | Cellular component | perinuclear endoplasmic reticulum lumen |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0062023 | Cellular component | collagen-containing extracellular matrix |
GO_0005829 | Cellular component | cytosol |
GO_0045202 | Cellular component | synapse |
GO_0097440 | Cellular component | apical dendrite |
GO_0051787 | Molecular function | misfolded protein binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0048156 | Molecular function | tau protein binding |
GO_0001540 | Molecular function | amyloid-beta binding |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0051082 | Molecular function | unfolded protein binding |
GO_0050750 | Molecular function | low-density lipoprotein particle receptor binding |
GO_0140597 | Molecular function | protein carrier chaperone |
GO_0051087 | Molecular function | protein-folding chaperone binding |
GO_0005515 | Molecular function | protein binding |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | CLU |
Protein name | Clusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)] Apolipoprotein J Clusterin |
Synonyms | APOJ AAG4 CLI KUB1 |
Description | FUNCTION: [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins . Prevents stress-induced aggregation of blood plasma proteins . Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) . Does not require ATP . Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 . Does not refold proteins by itself . Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation . Protects cells against apoptosis and against cytolysis by complement . Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins . Promotes proteasomal degradation of COMMD1 and IKBKB . Modulates NF-kappa-B transcriptional activity . A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis . Plays a role in the regulation of cell proliferation . An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 . Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity . Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). .; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. .; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity . Promotes cell death through interaction with BCL2L1 that releases and activates BAX . . |
Accessions | E7ERK6 ENST00000522238.1 ENST00000521770.1 ENST00000520491.5 ENST00000519472.5 Q8IWM0 ENST00000519742.5 ENST00000522098.1 E7ETB4 E5RH61 E5RJD6 H0YC35 ENST00000523396.1 H0YAS8 E5RGB0 E5RJZ5 ENST00000560566.5 ENST00000316403.15 [P10909-1] ENST00000523589.5 P10909 ENST00000520796.5 E5RG36 ENST00000405140.7 [P10909-1] H0YLK8 ENST00000523500.5 [P10909-1] ENST00000522413.5 |