CLU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905908Biological processpositive regulation of amyloid fibril formation
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0032286Biological processcentral nervous system myelin maintenance
GO_0006956Biological processcomplement activation
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_1902847Biological processregulation of neuronal signal transduction
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0050821Biological processprotein stabilization
GO_0000902Biological processcell morphogenesis
GO_0061518Biological processmicroglial cell proliferation
GO_0045087Biological processinnate immune response
GO_1900221Biological processregulation of amyloid-beta clearance
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0010628Biological processpositive regulation of gene expression
GO_0051131Biological processchaperone-mediated protein complex assembly
GO_0042981Biological processregulation of apoptotic process
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_1902998Biological processpositive regulation of neurofibrillary tangle assembly
GO_0006629Biological processlipid metabolic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0017038Biological processprotein import
GO_0001774Biological processmicroglial cell activation
GO_0061077Biological processchaperone-mediated protein folding
GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_1903573Biological processnegative regulation of response to endoplasmic reticulum stress
GO_0006958Biological processcomplement activation, classical pathway
GO_1902004Biological processpositive regulation of amyloid-beta formation
GO_1902230Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_1905907Biological processnegative regulation of amyloid fibril formation
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0042127Biological processregulation of cell population proliferation
GO_0009615Biological processresponse to virus
GO_0043691Biological processreverse cholesterol transport
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0061740Biological processprotein targeting to lysosome involved in chaperone-mediated autophagy
GO_0051788Biological processresponse to misfolded protein
GO_0002434Biological processimmune complex clearance
GO_0005856Cellular componentcytoskeleton
GO_0009986Cellular componentcell surface
GO_0071944Cellular componentcell periphery
GO_0005634Cellular componentnucleus
GO_0005576Cellular componentextracellular region
GO_0097418Cellular componentneurofibrillary tangle
GO_0070062Cellular componentextracellular exosome
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005615Cellular componentextracellular space
GO_0034366Cellular componentspherical high-density lipoprotein particle
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0005743Cellular componentmitochondrial inner membrane
GO_0042583Cellular componentchromaffin granule
GO_0072562Cellular componentblood microparticle
GO_0005737Cellular componentcytoplasm
GO_0099020Cellular componentperinuclear endoplasmic reticulum lumen
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0097440Cellular componentapical dendrite
GO_0051787Molecular functionmisfolded protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0048156Molecular functiontau protein binding
GO_0001540Molecular functionamyloid-beta binding
GO_0005102Molecular functionsignaling receptor binding
GO_0051082Molecular functionunfolded protein binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0140597Molecular functionprotein carrier chaperone
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005515Molecular functionprotein binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameCLU
Protein nameClusterin (Aging-associated gene 4 protein) (Apolipoprotein J) (Apo-J) (Complement cytolysis inhibitor) (CLI) (Complement-associated protein SP-40,40) (Ku70-binding protein 1) (NA1/NA2) (Sulfated glycoprotein 2) (SGP-2) (Testosterone-repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain (ApoJalpha) (Complement cytolysis inhibitor a chain) (SP-40,40 beta-chain); Clusterin alpha chain (ApoJbeta) (Complement cytolysis inhibitor b chain) (SP-40,40 alpha-chain)]
Apolipoprotein J
Clusterin
SynonymsAPOJ
AAG4
CLI
KUB1
DescriptionFUNCTION: [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins . Prevents stress-induced aggregation of blood plasma proteins . Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) . Does not require ATP . Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 . Does not refold proteins by itself . Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation . Protects cells against apoptosis and against cytolysis by complement . Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins . Promotes proteasomal degradation of COMMD1 and IKBKB . Modulates NF-kappa-B transcriptional activity . A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis . Plays a role in the regulation of cell proliferation . An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 . Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity . Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). .; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. .; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity . Promotes cell death through interaction with BCL2L1 that releases and activates BAX . .

AccessionsE7ERK6
ENST00000522238.1
ENST00000521770.1
ENST00000520491.5
ENST00000519472.5
Q8IWM0
ENST00000519742.5
ENST00000522098.1
E7ETB4
E5RH61
E5RJD6
H0YC35
ENST00000523396.1
H0YAS8
E5RGB0
E5RJZ5
ENST00000560566.5
ENST00000316403.15 [P10909-1]
ENST00000523589.5
P10909
ENST00000520796.5
E5RG36
ENST00000405140.7 [P10909-1]
H0YLK8
ENST00000523500.5 [P10909-1]
ENST00000522413.5