HTR1D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HTR1D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR1D at tissue level.

III. Associated gene sets

GO_0007198Biological processadenylate cyclase-inhibiting serotonin receptor signaling pathway
GO_0014827Biological processintestine smooth muscle contraction
GO_0050795Biological processregulation of behavior
GO_0042310Biological processvasoconstriction
GO_0007268Biological processchemical synaptic transmission
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0040012Biological processregulation of locomotion
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0030594Molecular functionneurotransmitter receptor activity

IV. Literature review

[source]
Gene nameHTR1D
Protein name5-hydroxytryptamine receptor 1D (5-HT-1D) (5-HT1D) (Serotonin 1D alpha receptor) (5-HT-1D-alpha) (Serotonin receptor 1D)
SynonymsHTR1DA
HTRL
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction. .

AccessionsENST00000374619.2
P28221