C4B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of C4B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of C4B at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0006956Biological processcomplement activation
GO_0006958Biological processcomplement activation, classical pathway
GO_2000427Biological processpositive regulation of apoptotic cell clearance
GO_0032490Biological processdetection of molecule of bacterial origin
GO_0008228Biological processopsonization
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0030425Cellular componentdendrite
GO_0072562Cellular componentblood microparticle
GO_0045202Cellular componentsynapse
GO_0106139Cellular componentsymbiont cell surface
GO_0030424Cellular componentaxon
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0030246Molecular functioncarbohydrate binding
GO_0001848Molecular functioncomplement binding

IV. Literature review

[source]
Gene nameC4B
Protein nameComplement C4B1a (Complement C4B2) (Complement C4B5)
C4B1 (C4B2) (C4B3) (C4B5)
Complement protein C4B frameshift mutant
Complement C4-B (Complement C4B (Chido blood group))
Complement C4-B
Complement component 4B
Complement C4B (Chido blood group)
Complement C4-B (Basic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3) [Cleaved into: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain]
C4B1
C4B
C4B2 (C4B5)
SynonymsCPAMD3;
CO4
C4B_2
DescriptionFUNCTION: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; FUNCTION: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

AccessionsQ6U2L6
F5GXS0
A0A140TA29
Q9UMV1
P0C0L5
Q6U2M2
ENST00000375177.9
ENST00000425700.3
ENST00000649658.1
ENST00000552464.2
ENST00000435363.7
ENST00000411583.6
Q6U2H4
A0A3B3ISA6
ENST00000546399.2
Q6U2E7
ENST00000548301.2
ENST00000435500.6
Q6U2E0
ENST00000449788.6
ENST00000647698.1
ENST00000548530.2
Q9UNU2
A0A0G2JL54
A0A3B3ISD7
R9QA77