EEF2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	51 studies	77% ± 23%	Explore
endothelial cell	46 studies	60% ± 23%	Explore
macrophage	44 studies	60% ± 21%	Explore
natural killer cell	43 studies	66% ± 19%	Explore
fibroblast	43 studies	69% ± 26%	Explore
T cell	41 studies	65% ± 26%	Explore
CD8-positive, alpha-beta T cell	38 studies	69% ± 21%	Explore
CD4-positive, alpha-beta T cell	36 studies	78% ± 21%	Explore
pericyte	34 studies	71% ± 26%	Explore
conventional dendritic cell	31 studies	80% ± 16%	Explore
plasmacytoid dendritic cell	29 studies	81% ± 19%	Explore
plasma cell	28 studies	72% ± 23%	Explore
smooth muscle cell	27 studies	76% ± 22%	Explore
classical monocyte	27 studies	71% ± 15%	Explore
regulatory T cell	27 studies	83% ± 15%	Explore
dendritic cell	26 studies	73% ± 24%	Explore
epithelial cell	26 studies	70% ± 24%	Explore
non-classical monocyte	25 studies	76% ± 13%	Explore
monocyte	24 studies	58% ± 24%	Explore
mast cell	23 studies	55% ± 21%	Explore
endothelial cell of lymphatic vessel	23 studies	70% ± 22%	Explore
mature NK T cell	22 studies	64% ± 19%	Explore
basal cell	22 studies	76% ± 20%	Explore
gamma-delta T cell	20 studies	78% ± 16%	Explore
memory B cell	20 studies	92% ± 7%	Explore
naive B cell	20 studies	83% ± 14%	Explore
connective tissue cell	20 studies	75% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	82% ± 16%	Explore
ciliated cell	17 studies	56% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	70% ± 21%	Explore
mucosal invariant T cell	16 studies	79% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	88% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	70% ± 17%	Explore
astrocyte	14 studies	33% ± 20%	Explore
capillary endothelial cell	14 studies	52% ± 22%	Explore
myofibroblast cell	14 studies	82% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	79% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	77% ± 16%	Explore
endothelial cell of artery	13 studies	61% ± 21%	Explore
vein endothelial cell	13 studies	64% ± 24%	Explore
endothelial cell of vascular tree	13 studies	69% ± 25%	Explore
myeloid cell	13 studies	69% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	66% ± 19%	Explore
innate lymphoid cell	12 studies	75% ± 14%	Explore
plasmablast	12 studies	85% ± 13%	Explore
secretory cell	12 studies	79% ± 12%	Explore
microglial cell	12 studies	42% ± 24%	Explore
goblet cell	12 studies	56% ± 24%	Explore
type I pneumocyte	11 studies	55% ± 25%	Explore
club cell	11 studies	65% ± 26%	Explore
leukocyte	11 studies	62% ± 22%	Explore
progenitor cell	11 studies	75% ± 30%	Explore
erythrocyte	11 studies	58% ± 26%	Explore
type II pneumocyte	10 studies	70% ± 27%	Explore
T follicular helper cell	10 studies	82% ± 12%	Explore
glutamatergic neuron	10 studies	34% ± 16%	Explore
abnormal cell	10 studies	76% ± 22%	Explore
neuron	10 studies	59% ± 30%	Explore
mesothelial cell	10 studies	85% ± 18%	Explore
IgG plasma cell	10 studies	62% ± 21%	Explore
oligodendrocyte precursor cell	10 studies	36% ± 25%	Explore
oligodendrocyte	9 studies	30% ± 10%	Explore
IgA plasma cell	9 studies	65% ± 24%	Explore
hematopoietic stem cell	9 studies	80% ± 33%	Explore
platelet	8 studies	45% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	74% ± 14%	Explore
alveolar macrophage	7 studies	57% ± 23%	Explore
mononuclear phagocyte	7 studies	59% ± 27%	Explore
neutrophil	7 studies	44% ± 14%	Explore
epithelial cell of proximal tubule	7 studies	63% ± 20%	Explore
enterocyte	7 studies	63% ± 26%	Explore
precursor B cell	7 studies	81% ± 25%	Explore
ionocyte	6 studies	69% ± 9%	Explore
respiratory goblet cell	6 studies	65% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	84% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	64% ± 20%	Explore
renal alpha-intercalated cell	6 studies	83% ± 11%	Explore
enteroendocrine cell	6 studies	74% ± 25%	Explore
erythroblast	6 studies	61% ± 26%	Explore
transit amplifying cell	6 studies	61% ± 29%	Explore
brush cell	6 studies	66% ± 32%	Explore
immature B cell	6 studies	92% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	86% ± 11%	Explore
GABAergic neuron	6 studies	35% ± 9%	Explore
interneuron	6 studies	47% ± 24%	Explore
CD4-positive helper T cell	5 studies	68% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	81% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	70% ± 11%	Explore
hematopoietic precursor cell	5 studies	86% ± 19%	Explore
exhausted T cell	5 studies	78% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	81% ± 16%	Explore
intestinal crypt stem cell	5 studies	76% ± 25%	Explore
amacrine cell	5 studies	58% ± 23%	Explore
retinal ganglion cell	5 studies	76% ± 33%	Explore
retinal cone cell	5 studies	56% ± 30%	Explore
retinal rod cell	5 studies	43% ± 21%	Explore
lymphocyte	5 studies	71% ± 27%	Explore
pro-B cell	5 studies	78% ± 30%	Explore
neuroendocrine cell	5 studies	77% ± 16%	Explore
T-helper 17 cell	5 studies	87% ± 13%	Explore
group 3 innate lymphoid cell	5 studies	90% ± 7%	Explore
mucus secreting cell	5 studies	63% ± 28%	Explore
double negative thymocyte	5 studies	87% ± 6%	Explore
intermediate monocyte	5 studies	73% ± 21%	Explore
hepatocyte	5 studies	57% ± 23%	Explore
granulocyte	5 studies	71% ± 10%	Explore
deuterosomal cell	4 studies	48% ± 9%	Explore
duct epithelial cell	4 studies	84% ± 4%	Explore
squamous epithelial cell	4 studies	53% ± 19%	Explore
pancreatic A cell	4 studies	80% ± 19%	Explore
type B pancreatic cell	4 studies	82% ± 22%	Explore
glomerular endothelial cell	4 studies	46% ± 14%	Explore
OFF-bipolar cell	4 studies	59% ± 30%	Explore
ON-bipolar cell	4 studies	55% ± 30%	Explore
megakaryocyte	4 studies	45% ± 19%	Explore
retina horizontal cell	4 studies	60% ± 24%	Explore
retinal pigment epithelial cell	4 studies	51% ± 30%	Explore
adventitial cell	4 studies	76% ± 11%	Explore
inflammatory macrophage	4 studies	61% ± 13%	Explore
acinar cell	4 studies	75% ± 25%	Explore
muscle cell	4 studies	49% ± 19%	Explore
germinal center B cell	4 studies	88% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	91% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	70% ± 21%	Explore
IgM plasma cell	4 studies	66% ± 23%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	80% ± 30%	Explore
glial cell	4 studies	56% ± 28%	Explore
T-helper 1 cell	4 studies	91% ± 4%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	81% ± 14%	Explore
hillock cell	3 studies	72% ± 24%	Explore
precursor cell	3 studies	96% ± 3%	Explore
pancreatic D cell	3 studies	91% ± 3%	Explore
monocyte-derived dendritic cell	3 studies	85% ± 15%	Explore
kidney connecting tubule epithelial cell	3 studies	69% ± 18%	Explore
podocyte	3 studies	88% ± 7%	Explore
renal beta-intercalated cell	3 studies	97% ± 2%	Explore
neural crest cell	3 studies	95% ± 4%	Explore
paneth cell	3 studies	79% ± 12%	Explore
retinal bipolar neuron	3 studies	68% ± 24%	Explore
GABAergic amacrine cell	3 studies	42% ± 18%	Explore
glycinergic amacrine cell	3 studies	37% ± 16%	Explore
renal principal cell	3 studies	66% ± 12%	Explore
thymocyte	3 studies	85% ± 11%	Explore
extravillous trophoblast	3 studies	97% ± 2%	Explore
placental villous trophoblast	3 studies	96% ± 2%	Explore
common myeloid progenitor	3 studies	63% ± 34%	Explore
serous secreting cell	3 studies	77% ± 4%	Explore
tissue-resident macrophage	3 studies	55% ± 26%	Explore
follicular B cell	3 studies	77% ± 15%	Explore
intraepithelial lymphocyte	3 studies	69% ± 19%	Explore
Mueller cell	3 studies	57% ± 7%	Explore
rod bipolar cell	3 studies	45% ± 21%	Explore
cardiac muscle cell	3 studies	31% ± 11%	Explore
chondrocyte	3 studies	50% ± 26%	Explore
adipocyte	3 studies	21% ± 4%	Explore
myoepithelial cell	3 studies	95% ± 2%	Explore
pancreatic ductal cell	3 studies	80% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	66% ± 34%	Explore
keratinocyte	3 studies	87% ± 12%	Explore
melanocyte	3 studies	68% ± 19%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	92% ± 2%	Explore
double-positive, alpha-beta thymocyte	3 studies	95% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	91% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	78% ± 14%	Explore
lung	19 studies	67% ± 17%	Explore
brain	18 studies	32% ± 12%	Explore
intestine	13 studies	66% ± 26%	Explore
kidney	9 studies	64% ± 22%	Explore
eye	9 studies	50% ± 23%	Explore
liver	8 studies	52% ± 24%	Explore
bone marrow	6 studies	66% ± 21%	Explore
lymph node	6 studies	88% ± 4%	Explore
pancreas	5 studies	74% ± 24%	Explore
placenta	5 studies	67% ± 29%	Explore
uterus	5 studies	76% ± 18%	Explore
adipose	4 studies	43% ± 25%	Explore
breast	4 studies	82% ± 9%	Explore
prostate	4 studies	72% ± 23%	Explore
heart	3 studies	33% ± 17%	Explore
adrenal gland	3 studies	67% ± 22%	Explore
esophagus	3 studies	72% ± 19%	Explore
skin	3 studies	65% ± 25%	Explore
thymus	3 studies	74% ± 34%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	130404.07	1445 / 1445	100%	1869.99	183 / 183
pancreas	100%	187967.64	328 / 328	100%	1702.90	178 / 178
thymus	100%	107104.99	653 / 653	100%	2661.75	605 / 605
prostate	100%	103310.38	245 / 245	100%	3996.97	501 / 502
intestine	100%	126593.46	966 / 966	100%	2743.11	525 / 527
skin	100%	163936.36	1809 / 1809	99%	2874.32	469 / 472
stomach	100%	115715.52	359 / 359	99%	2340.31	284 / 286
breast	100%	131228.42	459 / 459	99%	2148.69	1110 / 1118
kidney	100%	81481.45	89 / 89	99%	2004.68	894 / 901
ovary	100%	206595.97	180 / 180	99%	1520.65	426 / 430
uterus	100%	128466.36	170 / 170	99%	1659.67	454 / 459
lung	100%	90819.93	577 / 578	99%	1693.25	1143 / 1155
bladder	100%	120394.86	21 / 21	98%	1844.62	496 / 504
brain	98%	66041.42	2593 / 2642	100%	2135.73	704 / 705
adrenal gland	100%	115596.91	258 / 258	97%	1611.55	223 / 230
liver	99%	56543.58	223 / 226	97%	1220.11	392 / 406
adipose	100%	130463.46	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	5995.18	80 / 80
lymph node	0%	0	0 / 0	100%	2616.20	29 / 29
muscle	100%	195636.80	803 / 803	0%	0	0 / 0
spleen	100%	81460.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	1996.78	45 / 45
ureter	0%	0	0 / 0	100%	976.01	1 / 1
blood vessel	100%	101134.66	1334 / 1335	0%	0	0 / 0
peripheral blood	98%	97417.66	906 / 929	0%	0	0 / 0
heart	97%	91631.78	831 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002244	Biological process	hematopoietic progenitor cell differentiation
GO_0006414	Biological process	translational elongation
GO_0045727	Biological process	positive regulation of translation
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0005840	Cellular component	ribosome
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0034774	Cellular component	secretory granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0016235	Cellular component	aggresome
GO_0005634	Cellular component	nucleus
GO_0043022	Molecular function	ribosome binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0005525	Molecular function	GTP binding
GO_0003723	Molecular function	RNA binding
GO_0003746	Molecular function	translation elongation factor activity
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

Gene name	EEF2
Protein name	Eukaryotic translation elongation factor 2 EEF2 protein Elongation factor 2 (EF-2) (EC 3.6.5.-)
Synonyms	EF2
Description	FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation . During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively . Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome . .
Accessions	P13639 Q6PK56 ENST00000309311.7 ENST00000600794.1 M0R0I6

EEF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review