I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 4 studies | 22% ± 5% | |
| hepatocyte | 3 studies | 33% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retina horizontal cell | 4 studies | 22% ± 5% | |
| hepatocyte | 3 studies | 33% ± 15% |
Insufficient scRNA-seq data for expression of CHRNA4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1650.74 | 2637 / 2642 | 78% | 5.98 | 551 / 705 |
| liver | 99% | 10546.86 | 223 / 226 | 37% | 3.26 | 150 / 406 |
| kidney | 75% | 975.60 | 67 / 89 | 2% | 0.05 | 18 / 901 |
| spleen | 59% | 327.79 | 143 / 241 | 0% | 0 | 0 / 0 |
| thymus | 45% | 163.75 | 295 / 653 | 13% | 0.37 | 77 / 605 |
| adrenal gland | 16% | 51.41 | 42 / 258 | 10% | 1.15 | 23 / 230 |
| prostate | 13% | 54.51 | 32 / 245 | 0% | 0.00 | 1 / 502 |
| ovary | 5% | 9.08 | 9 / 180 | 6% | 0.21 | 25 / 430 |
| uterus | 2% | 4.71 | 3 / 170 | 3% | 0.09 | 13 / 459 |
| lung | 1% | 1.47 | 5 / 578 | 2% | 0.04 | 20 / 1155 |
| breast | 0% | 1.05 | 1 / 459 | 2% | 0.08 | 26 / 1118 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.17 | 2 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.05 | 1 / 45 |
| esophagus | 0% | 0.94 | 7 / 1445 | 1% | 0.02 | 2 / 183 |
| skin | 0% | 0.45 | 4 / 1809 | 1% | 0.03 | 6 / 472 |
| pancreas | 0% | 0 | 0 / 328 | 1% | 0.02 | 2 / 178 |
| stomach | 0% | 0 | 0 / 359 | 1% | 0.02 | 2 / 286 |
| intestine | 0% | 0.14 | 1 / 966 | 1% | 0.04 | 3 / 527 |
| heart | 1% | 1.13 | 5 / 861 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 0% | 0.01 | 2 / 504 |
| adipose | 0% | 1.28 | 3 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019233 | Biological process | sensory perception of pain |
| GO_0014059 | Biological process | regulation of dopamine secretion |
| GO_0006281 | Biological process | DNA repair |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_0051899 | Biological process | membrane depolarization |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0007165 | Biological process | signal transduction |
| GO_0034220 | Biological process | monoatomic ion transmembrane transport |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0095500 | Biological process | acetylcholine receptor signaling pathway |
| GO_0035095 | Biological process | behavioral response to nicotine |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0042113 | Biological process | B cell activation |
| GO_0035094 | Biological process | response to nicotine |
| GO_0050890 | Biological process | cognition |
| GO_0001508 | Biological process | action potential |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0007271 | Biological process | synaptic transmission, cholinergic |
| GO_0050877 | Biological process | nervous system process |
| GO_0006816 | Biological process | calcium ion transport |
| GO_0060080 | Biological process | inhibitory postsynaptic potential |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005892 | Cellular component | acetylcholine-gated channel complex |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030425 | Cellular component | dendrite |
| GO_0045202 | Cellular component | synapse |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0015464 | Molecular function | acetylcholine receptor activity |
| GO_0015276 | Molecular function | ligand-gated monoatomic ion channel activity |
| GO_0042166 | Molecular function | acetylcholine binding |
| GO_0022848 | Molecular function | acetylcholine-gated monoatomic cation-selective channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CHRNA4 |
| Protein name | Neuronal acetylcholine receptor alpha-4 subunit Cholinergic receptor nicotinic alpha 4 subunit Neuronal acetylcholine receptor alpha 4 subunit Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 protein |
| Synonyms | NACRA4 |
| Description | FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. . FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. . |
| Accessions | ENST00000627000.1 P43681 A0A6Q8PG41 A0A0D9SFU6 ENST00000675470.1 Q5EIU9 Q5EIV0 Q4VAQ3 Q5RLM1 ENST00000370263.9 [P43681-1] H0YBH1 ENST00000498043.6 |
