PTPRZ1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031641Biological processregulation of myelination
GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0006470Biological processprotein dephosphorylation
GO_0007611Biological processlearning or memory
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0007409Biological processaxonogenesis
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0048709Biological processoligodendrocyte differentiation
GO_0007417Biological processcentral nervous system development
GO_0070445Biological processregulation of oligodendrocyte progenitor proliferation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045202Cellular componentsynapse
GO_0072534Cellular componentperineuronal net
GO_0005001Molecular functiontransmembrane receptor protein tyrosine phosphatase activity
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRZ1
Protein nameReceptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)
Protein tyrosine phosphatase receptor type Z1
protein-tyrosine-phosphatase (EC 3.1.3.48)
SynonymsPTPZ
PTPRZ
PTPRZ2
HTPZP2
DescriptionFUNCTION: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). .

AccessionsENST00000650826.1
ENST00000651390.1
ENST00000393386.7 [P23471-1]
ENST00000651841.1
ENST00000650728.1
A0A494C1F0
ENST00000651842.1
A0A494C1J5
ENST00000650681.1
A0A494C0U4
ENST00000652298.1 [P23471-2]
A0A494C1B4
ENST00000651863.1
ENST00000652054.1
P23471
A0A494C036
A0A494C0V2
ENST00000651065.1
ENST00000651320.1
A0A494C1R4
ENST00000652708.1
A0A494C055
ENST00000449182.1 [P23471-3]
A0A494C087
A0A494C1H9