I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal ganglion cell | 4 studies | 62% ± 27% | |
| GABAergic neuron | 3 studies | 30% ± 11% | |
| neuron | 3 studies | 31% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal ganglion cell | 4 studies | 62% ± 27% | |
| GABAergic neuron | 3 studies | 30% ± 11% | |
| neuron | 3 studies | 31% ± 11% |
Insufficient scRNA-seq data for expression of ACHE at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 97% | 3576.34 | 2553 / 2642 | 98% | 17.79 | 689 / 705 |
| intestine | 93% | 840.50 | 895 / 966 | 72% | 11.95 | 381 / 527 |
| prostate | 95% | 1086.94 | 232 / 245 | 67% | 6.12 | 337 / 502 |
| pancreas | 39% | 248.34 | 127 / 328 | 85% | 17.54 | 152 / 178 |
| lung | 73% | 496.68 | 421 / 578 | 48% | 9.50 | 553 / 1155 |
| kidney | 56% | 313.25 | 50 / 89 | 49% | 6.09 | 438 / 901 |
| stomach | 29% | 166.76 | 103 / 359 | 71% | 17.14 | 202 / 286 |
| muscle | 99% | 3680.35 | 796 / 803 | 0% | 0 | 0 / 0 |
| uterus | 66% | 464.01 | 113 / 170 | 29% | 4.73 | 135 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 13.56 | 26 / 29 |
| ovary | 74% | 494.26 | 133 / 180 | 11% | 0.71 | 47 / 430 |
| adrenal gland | 19% | 133.43 | 48 / 258 | 63% | 25.30 | 145 / 230 |
| esophagus | 33% | 148.18 | 482 / 1445 | 48% | 16.54 | 87 / 183 |
| thymus | 42% | 218.12 | 277 / 653 | 25% | 4.91 | 151 / 605 |
| spleen | 67% | 356.42 | 162 / 241 | 0% | 0 | 0 / 0 |
| bladder | 29% | 89.76 | 6 / 21 | 38% | 4.96 | 194 / 504 |
| liver | 29% | 184.24 | 65 / 226 | 35% | 4.69 | 143 / 406 |
| heart | 51% | 497.23 | 438 / 861 | 0% | 0 | 0 / 0 |
| breast | 33% | 159.58 | 153 / 459 | 12% | 1.20 | 131 / 1118 |
| peripheral blood | 37% | 247.57 | 348 / 929 | 0% | 0 | 0 / 0 |
| skin | 8% | 28.21 | 137 / 1809 | 28% | 2.11 | 131 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 2.27 | 13 / 45 |
| eye | 0% | 0 | 0 / 0 | 16% | 1.15 | 13 / 80 |
| adipose | 14% | 63.84 | 171 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 11% | 48.46 | 145 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0031623 | Biological process | receptor internalization |
| GO_0001507 | Biological process | acetylcholine catabolic process in synaptic cleft |
| GO_0095500 | Biological process | acetylcholine receptor signaling pathway |
| GO_0001919 | Biological process | regulation of receptor recycling |
| GO_0060041 | Biological process | retina development in camera-type eye |
| GO_0007155 | Biological process | cell adhesion |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0006581 | Biological process | acetylcholine catabolic process |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0032223 | Biological process | negative regulation of synaptic transmission, cholinergic |
| GO_0007416 | Biological process | synapse assembly |
| GO_0042982 | Biological process | amyloid precursor protein metabolic process |
| GO_0002076 | Biological process | osteoblast development |
| GO_0007399 | Biological process | nervous system development |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031594 | Cellular component | neuromuscular junction |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0009986 | Cellular component | cell surface |
| GO_0045202 | Cellular component | synapse |
| GO_0043083 | Cellular component | synaptic cleft |
| GO_0005604 | Cellular component | basement membrane |
| GO_0098552 | Cellular component | side of membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0017171 | Molecular function | serine hydrolase activity |
| GO_0016787 | Molecular function | hydrolase activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0042166 | Molecular function | acetylcholine binding |
| GO_0003990 | Molecular function | acetylcholinesterase activity |
| GO_0043236 | Molecular function | laminin binding |
| GO_0005518 | Molecular function | collagen binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004104 | Molecular function | cholinesterase activity |
| Gene name | ACHE |
| Protein name | N-terminal extended acetylcholinesterase Carboxylic ester hydrolase (EC 3.1.1.-) Acetylcholinesterase (AChE) (EC 3.1.1.7) Acetylcholinesterase Acetylcholinesterase (Cartwright blood group) Acetylcholinesterase (EC 3.1.1.7) |
| Synonyms | |
| Description | FUNCTION: Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis. . |
| Accessions | A0A2S1KLT7 C9J2S3 A0A166IZM7 C9JZL6 ENST00000445236.3 P22303 A0A498U6H7 ENST00000441605.2 ENST00000454485.5 F8WAR7 ENST00000412389.5 [P22303-1] ENST00000428317.7 [P22303-1] ENST00000426415.5 ENST00000302913.8 [P22303-2] C9JD78 ENST00000411582.4 [P22303-2] A0A6M6AM29 F8WD68 Q13697 ENST00000440755.5 ENST00000430554.1 ENST00000419336.6 [P22303-3] F8WD34 Q6TQD3 ENST00000442452.1 A0A411EXG3 ENST00000241069.11 [P22303-1] A0A411EXG9 |
