I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 7 studies | 30% ± 17% | |
| GABAergic neuron | 3 studies | 27% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 7 studies | 30% ± 17% | |
| GABAergic neuron | 3 studies | 27% ± 4% |
Insufficient scRNA-seq data for expression of GABRA5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 72% | 3707.64 | 1897 / 2642 | 71% | 10.98 | 503 / 705 |
| esophagus | 50% | 715.97 | 724 / 1445 | 14% | 0.67 | 26 / 183 |
| eye | 0% | 0 | 0 / 0 | 36% | 4.09 | 29 / 80 |
| stomach | 16% | 114.33 | 59 / 359 | 5% | 0.14 | 15 / 286 |
| skin | 0% | 0.17 | 1 / 1809 | 18% | 1.48 | 85 / 472 |
| lung | 0% | 0 | 0 / 578 | 12% | 1.02 | 136 / 1155 |
| thymus | 0% | 0 | 0 / 653 | 11% | 2.81 | 69 / 605 |
| ovary | 0% | 0 | 0 / 180 | 8% | 0.14 | 33 / 430 |
| pancreas | 0% | 0 | 0 / 328 | 7% | 0.21 | 13 / 178 |
| uterus | 0% | 0 | 0 / 170 | 7% | 0.57 | 32 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.82 | 2 / 29 |
| adrenal gland | 0% | 0 | 0 / 258 | 7% | 0.55 | 15 / 230 |
| breast | 0% | 0 | 0 / 459 | 5% | 0.50 | 58 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.18 | 2 / 45 |
| prostate | 0% | 0 | 0 / 245 | 4% | 0.07 | 22 / 502 |
| liver | 0% | 0 | 0 / 226 | 3% | 0.26 | 14 / 406 |
| kidney | 0% | 0 | 0 / 89 | 3% | 0.11 | 28 / 901 |
| intestine | 1% | 1.84 | 5 / 966 | 2% | 0.04 | 8 / 527 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.14 | 8 / 504 |
| heart | 1% | 2.71 | 6 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0008306 | Biological process | associative learning |
| GO_0099505 | Biological process | regulation of presynaptic membrane potential |
| GO_1904862 | Biological process | inhibitory synapse assembly |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0090102 | Biological process | cochlea development |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0001662 | Biological process | behavioral fear response |
| GO_0060119 | Biological process | inner ear receptor cell development |
| GO_0051932 | Biological process | synaptic transmission, GABAergic |
| GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
| GO_0060384 | Biological process | innervation |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1902495 | Cellular component | transmembrane transporter complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0098794 | Cellular component | postsynapse |
| GO_0032809 | Cellular component | neuronal cell body membrane |
| GO_0043005 | Cellular component | neuron projection |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0005829 | Cellular component | cytosol |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_1902711 | Cellular component | GABA-A receptor complex |
| GO_0032590 | Cellular component | dendrite membrane |
| GO_0099634 | Cellular component | postsynaptic specialization membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004890 | Molecular function | GABA-A receptor activity |
| GO_0050811 | Molecular function | GABA receptor binding |
| GO_0022851 | Molecular function | GABA-gated chloride ion channel activity |
| GO_0099507 | Molecular function | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0008503 | Molecular function | benzodiazepine receptor activity |
| Gene name | GABRA5 |
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) Gamma-aminobutyric acid type A receptor subunit alpha5 Gamma-aminobutyric acid (GABA) A receptor, alpha 5, isoform CRA_a (cDNA FLJ56835, highly similar to Gamma-aminobutyric-acid receptor alpha-5 subunit) |
| Synonyms | hCG_1811407 |
| Description | FUNCTION: Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse . . |
| Accessions | ENST00000400081.7 P31644 G3V2K2 G3V2G8 ENST00000555182.5 ENST00000355395.9 ENST00000554038.5 G3V408 ENST00000335625.10 B4E1A2 ENST00000554083.1 ENST00000554599.5 G3V2Q9 G3V2Y5 G3V296 ENST00000554596.5 ENST00000555060.1 |
