HTR2C report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR2C at tissue level.

III. Associated gene sets

GO_0019934Biological processcGMP-mediated signaling
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0007631Biological processfeeding behavior
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0007210Biological processserotonin receptor signaling pathway
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0098664Biological processG protein-coupled serotonin receptor signaling pathway
GO_0032098Biological processregulation of appetite
GO_0010513Biological processpositive regulation of phosphatidylinositol biosynthetic process
GO_0007208Biological processphospholipase C-activating serotonin receptor signaling pathway
GO_0043397Biological processregulation of corticotropin-releasing hormone secretion
GO_0007268Biological processchemical synaptic transmission
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0031644Biological processregulation of nervous system process
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0001662Biological processbehavioral fear response
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0007626Biological processlocomotory behavior
GO_0005886Cellular componentplasma membrane
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0098666Cellular componentG protein-coupled serotonin receptor complex
GO_0042802Molecular functionidentical protein binding
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0051378Molecular functionserotonin binding
GO_0071886Molecular function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0001587Molecular functionGq/11-coupled serotonin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTR2C
Protein name5-hydroxytryptamine (Serotonin) receptor 2C
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)
5-hydroxytryptamine receptor 2C variant b
SynonymsHTR1C
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. .

AccessionsQ7Z579
ENST00000371950.3 [P28335-2]
B3VRF5
B3VRF0
P28335
ENST00000371951.5 [P28335-1]
ENST00000276198.6 [P28335-1]
B3VRE0
B3VRE5