CORO1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000394Biological processpositive regulation of lamellipodium morphogenesis
GO_0001755Biological processneural crest cell migration
GO_0044387Biological processnegative regulation of protein kinase activity by regulation of protein phosphorylation
GO_0090630Biological processactivation of GTPase activity
GO_0045184Biological processestablishment of protein localization
GO_0007165Biological processsignal transduction
GO_0051895Biological processnegative regulation of focal adhesion assembly
GO_0001932Biological processregulation of protein phosphorylation
GO_0090148Biological processmembrane fission
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0021591Biological processventricular system development
GO_0016197Biological processendosomal transport
GO_0097750Biological processendosome membrane tubulation
GO_1900024Biological processregulation of substrate adhesion-dependent cell spreading
GO_0007015Biological processactin filament organization
GO_0051893Biological processregulation of focal adhesion assembly
GO_0006909Biological processphagocytosis
GO_0022038Biological processcorpus callosum development
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_0010762Biological processregulation of fibroblast migration
GO_0010633Biological processnegative regulation of epithelial cell migration
GO_0010632Biological processregulation of epithelial cell migration
GO_1900027Biological processregulation of ruffle assembly
GO_0140285Biological processendosome fission
GO_0032587Cellular componentruffle membrane
GO_0042383Cellular componentsarcolemma
GO_0016600Cellular componentflotillin complex
GO_0005925Cellular componentfocal adhesion
GO_0015629Cellular componentactin cytoskeleton
GO_0030017Cellular componentsarcomere
GO_0045202Cellular componentsynapse
GO_0005938Cellular componentcell cortex
GO_0016328Cellular componentlateral plasma membrane
GO_0010008Cellular componentendosome membrane
GO_0030027Cellular componentlamellipodium
GO_0031982Cellular componentvesicle
GO_0051015Molecular functionactin filament binding
GO_0031267Molecular functionsmall GTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCORO1C
Protein nameCoronin
Coronin 1C
Coronin-1C (Coronin-3) (hCRNN4)
SynonymsCRNN4
CRN2
DescriptionFUNCTION: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 . Increases the presence of activated RAC1 at the leading edge of migrating cells . Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission . Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane . Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). .; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. .

AccessionsQ9ULV4
F8VSA4
ENST00000547294.5
ENST00000261401.8 [Q9ULV4-1]
ENST00000546571.5
ENST00000550542.5
F8VV53
ENST00000546705.5
F8VVB7
F8VRE9
F8VTT6
ENST00000421578.6
ENST00000552871.5
B4E3S0
ENST00000541050.5 [Q9ULV4-1]
ENST00000549772.5 [Q9ULV4-2]
F8W1H8
ENST00000420959.6 [Q9ULV4-3]
F8VUX3
ENST00000550032.5
ENST00000551550.5
ENST00000551044.1
H0YHL7