RPS27A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006412Biological processtranslation
GO_0019941Biological processmodification-dependent protein catabolic process
GO_0002181Biological processcytoplasmic translation
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0022626Cellular componentcytosolic ribosome
GO_0005886Cellular componentplasma membrane
GO_0022627Cellular componentcytosolic small ribosomal subunit
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032040Cellular componentsmall-subunit processome
GO_0030666Cellular componentendocytic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0010008Cellular componentendosome membrane
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0031386Molecular functionprotein tag activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003735Molecular functionstructural constituent of ribosome
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPS27A
Protein nameUbiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80)
RPS27A protein
Ubiquitin-40S ribosomal protein S27a
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
SynonymsUBA80
hCG_1987923
HEL112
UBCEP1
DescriptionFUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. .; FUNCTION: [Small ribosomal subunit protein eS31]: Component of the 40S subunit of the ribosome . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsP62979
B2RDW1
Q5RKT7
ENST00000272317.11
ENST00000404735.1
Q8WYN9
J3QTR3
ENST00000449323
Q49A90
ENST00000402285.7