Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 39% ± 21% | |
oligodendrocyte | 15 studies | 81% ± 10% | |
oligodendrocyte precursor cell | 13 studies | 46% ± 18% | |
fibroblast | 13 studies | 39% ± 16% | |
glutamatergic neuron | 12 studies | 56% ± 23% | |
GABAergic neuron | 9 studies | 56% ± 22% | |
pericyte | 9 studies | 39% ± 11% | |
smooth muscle cell | 8 studies | 36% ± 10% | |
microglial cell | 6 studies | 31% ± 13% | |
adipocyte | 6 studies | 38% ± 7% | |
neuron | 5 studies | 41% ± 14% | |
endothelial cell | 5 studies | 50% ± 12% | |
interneuron | 5 studies | 71% ± 13% | |
granule cell | 4 studies | 40% ± 10% | |
retinal ganglion cell | 4 studies | 51% ± 25% | |
retinal rod cell | 4 studies | 59% ± 14% | |
GABAergic interneuron | 3 studies | 40% ± 14% | |
epithelial cell | 3 studies | 33% ± 16% | |
connective tissue cell | 3 studies | 46% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 2766.06 | 652 / 653 | 95% | 19.37 | 573 / 605 |
prostate | 100% | 1166.59 | 245 / 245 | 89% | 2.47 | 449 / 502 |
adrenal gland | 98% | 2205.29 | 253 / 258 | 81% | 18.83 | 187 / 230 |
brain | 99% | 1330.64 | 2624 / 2642 | 80% | 3.93 | 562 / 705 |
lung | 100% | 1011.80 | 576 / 578 | 68% | 1.99 | 785 / 1155 |
breast | 69% | 327.58 | 319 / 459 | 83% | 5.09 | 931 / 1118 |
stomach | 82% | 337.60 | 295 / 359 | 54% | 1.47 | 155 / 286 |
kidney | 83% | 337.03 | 74 / 89 | 49% | 1.39 | 439 / 901 |
ovary | 94% | 824.62 | 170 / 180 | 37% | 1.11 | 158 / 430 |
bladder | 100% | 1108.95 | 21 / 21 | 30% | 0.75 | 149 / 504 |
uterus | 96% | 627.71 | 163 / 170 | 28% | 1.91 | 129 / 459 |
intestine | 79% | 489.72 | 760 / 966 | 38% | 0.76 | 198 / 527 |
blood vessel | 100% | 1748.60 | 1333 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1030.44 | 240 / 241 | 0% | 0 | 0 / 0 |
esophagus | 48% | 193.03 | 689 / 1445 | 46% | 1.17 | 85 / 183 |
heart | 84% | 608.31 | 726 / 861 | 0% | 0 | 0 / 0 |
pancreas | 2% | 5.70 | 7 / 328 | 66% | 1.56 | 118 / 178 |
adipose | 60% | 402.91 | 718 / 1204 | 0% | 0 | 0 / 0 |
skin | 7% | 20.97 | 119 / 1809 | 22% | 1.70 | 106 / 472 |
liver | 9% | 26.89 | 21 / 226 | 14% | 0.29 | 56 / 406 |
tonsil | 0% | 0 | 0 / 0 | 9% | 0.19 | 4 / 45 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.16 | 2 / 29 |
eye | 0% | 0 | 0 / 0 | 1% | 0.05 | 1 / 80 |
muscle | 1% | 2.18 | 6 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_2001222 | Biological process | regulation of neuron migration |
GO_0033564 | Biological process | anterior/posterior axon guidance |
GO_0051094 | Biological process | positive regulation of developmental process |
GO_1990791 | Biological process | dorsal root ganglion development |
GO_0007420 | Biological process | brain development |
GO_0006915 | Biological process | apoptotic process |
GO_0038007 | Biological process | netrin-activated signaling pathway |
GO_2000243 | Biological process | positive regulation of reproductive process |
GO_0061643 | Biological process | chemorepulsion of axon |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0035234 | Biological process | ectopic germ cell programmed cell death |
GO_0007411 | Biological process | axon guidance |
GO_0005886 | Cellular component | plasma membrane |
GO_0043025 | Cellular component | neuronal cell body |
GO_0030425 | Cellular component | dendrite |
GO_0009986 | Cellular component | cell surface |
GO_0030175 | Cellular component | filopodium |
GO_0045202 | Cellular component | synapse |
GO_0030426 | Cellular component | growth cone |
GO_0030027 | Cellular component | lamellipodium |
GO_0015631 | Molecular function | tubulin binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0005042 | Molecular function | netrin receptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0005043 | Molecular function | netrin receptor activity involved in chemorepulsion |
Gene name | UNC5C |
Protein name | Uncharacterized protein UNC5C Netrin receptor UNC5 Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) Unc-5 netrin receptor C |
Synonyms | UNC5H3 |
Description | FUNCTION: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). . FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. . |
Accessions | ENST00000453304.6 [O95185-1] E0CX15 ENST00000506749.5 [O95185-2] Q4W5H4 ENST00000513796.5 O95185 D6RE16 ENST00000504962.1 |