UNC5C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001222Biological processregulation of neuron migration
GO_0033564Biological processanterior/posterior axon guidance
GO_0051094Biological processpositive regulation of developmental process
GO_1990791Biological processdorsal root ganglion development
GO_0007420Biological processbrain development
GO_0006915Biological processapoptotic process
GO_0038007Biological processnetrin-activated signaling pathway
GO_2000243Biological processpositive regulation of reproductive process
GO_0061643Biological processchemorepulsion of axon
GO_0043065Biological processpositive regulation of apoptotic process
GO_0035234Biological processectopic germ cell programmed cell death
GO_0007411Biological processaxon guidance
GO_0005886Cellular componentplasma membrane
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0030175Cellular componentfilopodium
GO_0045202Cellular componentsynapse
GO_0030426Cellular componentgrowth cone
GO_0030027Cellular componentlamellipodium
GO_0015631Molecular functiontubulin binding
GO_0019901Molecular functionprotein kinase binding
GO_0005042Molecular functionnetrin receptor activity
GO_0005515Molecular functionprotein binding
GO_0005043Molecular functionnetrin receptor activity involved in chemorepulsion

IV. Literature review

[source]
Gene nameUNC5C
Protein nameUncharacterized protein UNC5C
Netrin receptor UNC5
Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)
Unc-5 netrin receptor C
SynonymsUNC5H3
DescriptionFUNCTION: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). .

FUNCTION: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. .

AccessionsENST00000453304.6 [O95185-1]
E0CX15
ENST00000506749.5 [O95185-2]
Q4W5H4
ENST00000513796.5
O95185
D6RE16
ENST00000504962.1