Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 10 studies | 46% ± 26% | |
| oligodendrocyte precursor cell | 9 studies | 34% ± 14% | |
| GABAergic neuron | 7 studies | 41% ± 21% | |
| interneuron | 4 studies | 50% ± 23% | |
| neuron | 3 studies | 28% ± 6% | |
| GABAergic interneuron | 3 studies | 20% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 45% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 2507.24 | 2626 / 2642 | 100% | 33.93 | 702 / 705 |
| pancreas | 99% | 586.14 | 325 / 328 | 83% | 7.44 | 148 / 178 |
| adrenal gland | 88% | 408.44 | 226 / 258 | 78% | 17.48 | 180 / 230 |
| breast | 87% | 417.93 | 400 / 459 | 78% | 13.96 | 867 / 1118 |
| prostate | 82% | 359.61 | 201 / 245 | 77% | 6.42 | 388 / 502 |
| lung | 61% | 180.09 | 353 / 578 | 59% | 5.06 | 686 / 1155 |
| uterus | 70% | 240.26 | 119 / 170 | 43% | 4.37 | 196 / 459 |
| ovary | 27% | 71.81 | 48 / 180 | 72% | 5.09 | 311 / 430 |
| blood vessel | 97% | 812.03 | 1299 / 1335 | 0% | 0 | 0 / 0 |
| heart | 83% | 450.16 | 714 / 861 | 0% | 0 | 0 / 0 |
| thymus | 5% | 13.85 | 34 / 653 | 77% | 6.20 | 466 / 605 |
| stomach | 67% | 244.43 | 242 / 359 | 13% | 0.83 | 37 / 286 |
| kidney | 26% | 76.42 | 23 / 89 | 54% | 8.70 | 488 / 901 |
| skin | 57% | 235.25 | 1031 / 1809 | 21% | 1.70 | 98 / 472 |
| intestine | 59% | 261.90 | 569 / 966 | 10% | 0.77 | 53 / 527 |
| adipose | 57% | 189.90 | 692 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 33% | 97.67 | 7 / 21 | 24% | 1.91 | 120 / 504 |
| muscle | 38% | 92.47 | 309 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 24% | 65.80 | 352 / 1445 | 9% | 0.64 | 17 / 183 |
| liver | 3% | 6.02 | 6 / 226 | 27% | 2.59 | 111 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 1.07 | 6 / 45 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.09 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0007628 | Biological process | adult walking behavior |
| GO_0007218 | Biological process | neuropeptide signaling pathway |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_0060079 | Biological process | excitatory postsynaptic potential |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_0060013 | Biological process | righting reflex |
| GO_0007340 | Biological process | acrosome reaction |
| GO_0060012 | Biological process | synaptic transmission, glycinergic |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0097112 | Biological process | gamma-aminobutyric acid receptor clustering |
| GO_0001964 | Biological process | startle response |
| GO_0007399 | Biological process | nervous system development |
| GO_0098690 | Cellular component | glycinergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1902495 | Cellular component | transmembrane transporter complex |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030425 | Cellular component | dendrite |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0045202 | Cellular component | synapse |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0099572 | Cellular component | postsynaptic specialization |
| GO_0016935 | Cellular component | glycine-gated chloride channel complex |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0005231 | Molecular function | excitatory extracellular ligand-gated monoatomic ion channel activity |
| GO_0016933 | Molecular function | extracellularly glycine-gated ion channel activity |
| GO_0016934 | Molecular function | extracellularly glycine-gated chloride channel activity |
| GO_0030594 | Molecular function | neurotransmitter receptor activity |
| GO_0016594 | Molecular function | glycine binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005254 | Molecular function | chloride channel activity |
| Gene name | GLRB |
| Protein name | Glycine receptor beta Glycine receptor subunit beta (Glycine receptor 58 kDa subunit) |
| Synonyms | |
| Description | FUNCTION: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine . Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . . |
| Accessions | ENST00000509282.1 [P48167-1] ENST00000541722.5 [P48167-2] ENST00000512619.5 ENST00000506411.5 D6R9Y9 ENST00000515642.5 D6RD86 P48167 ENST00000264428.9 [P48167-1] |
