PTPRN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001553Biological processluteinization
GO_1990502Biological processdense core granule maturation
GO_0035773Biological processinsulin secretion involved in cellular response to glucose stimulus
GO_0051046Biological processregulation of secretion
GO_0000302Biological processresponse to reactive oxygen species
GO_0030073Biological processinsulin secretion
GO_1904692Biological processpositive regulation of type B pancreatic cell proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0043679Cellular componentaxon terminus
GO_0005634Cellular componentnucleus
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0008021Cellular componentsynaptic vesicle
GO_0045202Cellular componentsynapse
GO_0030141Cellular componentsecretory granule
GO_0030658Cellular componenttransport vesicle membrane
GO_0005768Cellular componentendosome
GO_0008134Molecular functiontranscription factor binding
GO_0030507Molecular functionspectrin binding
GO_0005515Molecular functionprotein binding
GO_0044389Molecular functionubiquitin-like protein ligase binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRN
Protein namePTPRN protein
Protein tyrosine phosphatase receptor type N transcript variant 1
Protein tyrosine phosphatase, receptor type, N
Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]
Protein tyrosine phosphatase receptor type N
SynonymsICA512
hCG_15565
ICA3
DescriptionFUNCTION: Plays a role in vesicle-mediated secretory processes . Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation . Plays a role in insulin secretion in response to glucose stimuli . Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). .; FUNCTION: [ICA512-transmembrane fragment]: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. .; FUNCTION: [ICA512-cleaved cytosolic fragment]: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 . Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 . ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis . .

AccessionsENST00000409251.7 [Q16849-2]
H7C0U9
ENST00000440552.5
ENST00000442029.5
C9JR27
A0A4Y5WWT4
ENST00000606213.5
Q96IA0
ENST00000295718.7 [Q16849-1]
ENST00000423636.6 [Q16849-3]
ENST00000412847.5
Q7KZS4
C9JCQ0
Q16849
U3KQ66
C9JJL7
ENST00000451506.5
A0A1B0GX26
C9J392
ENST00000443981.5
ENST00000446182.5