DBH | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DBH at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	2405.61	226 / 226	70%	4.32	284 / 406
adrenal gland	99%	6195.75	256 / 258	66%	4274.63	152 / 230
thymus	95%	70.15	621 / 653	42%	1.06	253 / 605
kidney	99%	158.65	88 / 89	28%	0.65	248 / 901
lung	99%	117.55	574 / 578	19%	0.46	219 / 1155
pancreas	100%	175.30	327 / 328	15%	1.79	26 / 178
prostate	93%	69.98	229 / 245	18%	1.49	88 / 502
ovary	99%	64.68	179 / 180	6%	0.11	25 / 430
brain	81%	71.83	2132 / 2642	23%	0.43	159 / 705
uterus	89%	52.25	151 / 170	14%	0.36	66 / 459
spleen	100%	127.02	240 / 241	0%	0	0 / 0
stomach	89%	42.43	319 / 359	10%	0.18	28 / 286
intestine	75%	34.60	720 / 966	8%	0.51	42 / 527
bladder	76%	62.76	16 / 21	6%	0.83	31 / 504
esophagus	51%	16.77	732 / 1445	11%	0.20	20 / 183
heart	57%	30.26	488 / 861	0%	0	0 / 0
breast	47%	15.13	218 / 459	9%	0.18	102 / 1118
adipose	54%	19.67	652 / 1204	0%	0	0 / 0
skin	34%	10.25	617 / 1809	17%	0.35	79 / 472
lymph node	0%	0	0 / 0	31%	0.94	9 / 29
tonsil	0%	0	0 / 0	24%	0.46	11 / 45
blood vessel	23%	7.31	313 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	21%	0.36	17 / 80
peripheral blood	20%	5.91	185 / 929	0%	0	0 / 0
muscle	14%	4.02	116 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001974	Biological process	blood vessel remodeling
GO_1904705	Biological process	regulation of vascular associated smooth muscle cell proliferation
GO_0048149	Biological process	behavioral response to ethanol
GO_0042421	Biological process	norepinephrine biosynthetic process
GO_0002443	Biological process	leukocyte mediated immunity
GO_0045907	Biological process	positive regulation of vasoconstriction
GO_0008542	Biological process	visual learning
GO_1905562	Biological process	regulation of vascular endothelial cell proliferation
GO_0006589	Biological process	octopamine biosynthetic process
GO_0042596	Biological process	fear response
GO_0042711	Biological process	maternal behavior
GO_0048265	Biological process	response to pain
GO_0007268	Biological process	chemical synaptic transmission
GO_0050900	Biological process	leukocyte migration
GO_2001236	Biological process	regulation of extrinsic apoptotic signaling pathway
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0007613	Biological process	memory
GO_0001975	Biological process	response to amphetamine
GO_0042310	Biological process	vasoconstriction
GO_0042309	Biological process	homoiothermy
GO_0007626	Biological process	locomotory behavior
GO_0042593	Biological process	glucose homeostasis
GO_0042420	Biological process	dopamine catabolic process
GO_0005615	Cellular component	extracellular space
GO_0034466	Cellular component	chromaffin granule lumen
GO_0030667	Cellular component	secretory granule membrane
GO_0005576	Cellular component	extracellular region
GO_0034451	Cellular component	centriolar satellite
GO_0016020	Cellular component	membrane
GO_0042584	Cellular component	chromaffin granule membrane
GO_0034774	Cellular component	secretory granule lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0030658	Cellular component	transport vesicle membrane
GO_0031418	Molecular function	L-ascorbic acid binding
GO_0003824	Molecular function	catalytic activity
GO_0004500	Molecular function	dopamine beta-monooxygenase activity
GO_0005507	Molecular function	copper ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DBH
Protein name	Dopamine beta-hydroxylase (EC 1.14.17.1) Dopamine beta-hydroxylase (EC 1.14.17.1) (Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]
Synonyms
Description	FUNCTION: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. . FUNCTION: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. .
Accessions	P09172 ENST00000263611.3 ENST00000393056.8 Q5T382

DBH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review