PICK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021782Biological processglial cell development
GO_0034316Biological processnegative regulation of Arp2/3 complex-mediated actin nucleation
GO_0042149Biological processcellular response to glucose starvation
GO_0050796Biological processregulation of insulin secretion
GO_0015844Biological processmonoamine transport
GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0006886Biological processintracellular protein transport
GO_0060292Biological processlong-term synaptic depression
GO_0036294Biological processcellular response to decreased oxygen levels
GO_0002092Biological processpositive regulation of receptor internalization
GO_0043113Biological processreceptor clustering
GO_0097061Biological processdendritic spine organization
GO_0045161Biological processneuronal ion channel clustering
GO_0097062Biological processdendritic spine maintenance
GO_0006468Biological processprotein phosphorylation
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0098842Cellular componentpostsynaptic early endosome
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0042734Cellular componentpresynaptic membrane
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005080Molecular functionprotein kinase C binding
GO_0019904Molecular functionprotein domain specific binding
GO_0005543Molecular functionphospholipid binding
GO_0051015Molecular functionactin filament binding
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0071933Molecular functionArp2/3 complex binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0140090Molecular functionmembrane curvature sensor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePICK1
Protein nameProtein interacting with PRKCA 1
PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)
SynonymsPRKCABP
DescriptionFUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. .

FUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. .

AccessionsF6V3V1
ENST00000437453.5
ENST00000424694.5
F6VY12
F6V107
ENST00000435166.1
E7EX80
ENST00000426258.5
ENST00000432756.6
ENST00000404072.7 [Q9NRD5-1]
F6TII1
ENST00000445628.5
Q9NRD5
ENST00000356976.8 [Q9NRD5-1]